文章摘要
严 婷,李世芬,赵 岩.蓝莓对小鼠免疫功能的调节作用[J].南京医科大学学报,2008,28(11):1448~1450
蓝莓对小鼠免疫功能的调节作用
Effects of blueberry on immune modulation in rats
投稿时间:2008-09-25  
DOI:10.7655
中文关键词: 蓝莓  免疫调节  小鼠
英文关键词: blueberry  immune modulation  rats
基金项目:
作者单位
严 婷 南京医科大学公共卫生学院卫生分析检测中心,江苏 南京 210029 
李世芬  
赵 岩  
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中文摘要:
      目的:研究蓝莓对小鼠的免疫调节作用?方法:每组小鼠分别经口灌胃给予54?108?325 mg/(kg·bw)的蓝莓提取物及灭菌水30天后,观察其体重?测定其免疫器官指数?淋巴细胞增殖能力?小鼠迟发型变态反应?血清溶血素?吞噬细胞的吞噬功能及NK细胞活性?结果:325 mg/(kg·bw)组可增加小鼠耳壳重量?增强淋巴细胞增殖能力?提高小鼠碳廓清的能力,提高小鼠NK细胞和巨噬细胞活性;108 mg/(kg·bw)组可增加小鼠耳壳重量?血清的半数溶血值;54 mg/(kg· bw)组可提高小鼠NK细胞活性?结论:蓝莓具有增强小鼠免疫功能的作用?
英文摘要:
      Objective:To study the effects of the blueberry on immune modulation in rats. Methods:Rats were orally administered with blueberry extract and sterile water for 30 days at the dose of 54 mg,108 mg and 325 mg/(kg·bw). Weight,index of immune organs,proliferation ability of lymphocytes,DTH response,the level of serum HC50,NK cell activity and phagocytic function of macrophages were observed. Results:Compared with the control group,the blueberry could improve the capacities of lymphocyte proliferation induced by ConA,DTH response,the level of serum HC50,NK cell activity and macrophage in group of 325 mg/kg. It could improve DTH response and the level of serum HC50 in group of 108 mg/kg. And it could improve NK cell activity in group of 54 mg/kg. Conclusion:Blueberry has effects on promoting immune function in rats.
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