文章摘要
吴婷,丁新生,董海蓉,王蔚.MK-801对转Aβ42基因果蝇阿尔茨海默病模型的神经保护作用[J].南京医科大学学报,2008,28(12):1574~1577
MK-801对转Aβ42基因果蝇阿尔茨海默病模型的神经保护作用
The neuroprotective effects of MK-801 on Aβ42 transgenic drosophila model of Alzheimer’s disease
投稿时间:2008-06-22  
DOI:10.7655
中文关键词: 阿尔茨海默病  果蝇  Aβ42  MK-801
英文关键词: Alzheimer’s disease  drosophila  Aβ42  MK-801
基金项目:
作者单位
吴婷 南京医科大学第一附属医院神经内科,江苏 南京〓210029 
丁新生  
董海蓉  
王蔚  
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中文摘要:
      目的:探讨N-甲基-D-天冬氨酸(NMDA)受体拮抗剂MK-801拮抗阿尔茨海默病(AD)果蝇模型中Aβ42诱导的神经毒作用?方法:建立转Aβ42基因果蝇AD模型,用NMDA受体拮抗剂MK-801分别干预正常对照果蝇和转Aβ42基因AD模型果蝇,在整体动物水平上进行果蝇行为学检测,分别检测各组果蝇的嗅觉短期记忆能力?攀爬能力和平均寿命?结果:与Aβ42转基因组果蝇相比,Aβ42转基因果蝇喂食MK-801组的学习记忆能力?攀爬能力?平均寿命均有显著改善(P < 0.05),正常对照组和正常对照+MK801组的行为学检测无统计学差异?结论:在转Aβ42基因AD果蝇模型中,NMDA受体拮抗剂MK-801的干预有明显的神经保护作用,能减轻Aβ42诱导的神经毒作用?
英文摘要:
       Objective:To explore the neuroprotective effects of the N-methyl-D-aspartate(NMDA) receptor antagonist MK-801 on Aβ42 transgenic drosophila model of Alzheimer’s disease. Methods:Drosophila was designed into four groups:normal control,normal drosophila exposed to MK-801,Aβ42 transgenic drosophila and Aβ42 transgenic drosophila exposed to MK-801. And the olfactory associative learning assay,climbing assay and survival assay were performed in four groups of drosophila. Results:Compared with Aβ42 transgenic drosophila group,the associative learning ability,climbing ability and life span of Aβ42 transgenic drosophila applied with MK-801 group were significantly improved. Conclusion:In Aβ42 transgenic drosophila model of Alzheimer’s disease,MK-801 can reduce the neurotoxic effect induced by Aβ42.
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