文章摘要
吴 晋.血清抗心磷脂抗体?D-二聚体与急性脑梗死关系的研究[J].南京医科大学学报,2008,28(12):1595~1597
血清抗心磷脂抗体?D-二聚体与急性脑梗死关系的研究
Investigation of prognosis relationship between anti-cardiolipin antibodies?D-Dimer and the patients with acute cerebral infarction
投稿时间:2008-07-13  
DOI:10.7655
中文关键词: 抗心磷脂抗体  D-二聚体  急性脑梗死
英文关键词: anti-cardiolipin antibodies  D-Dimer  acute cerebral infarction
基金项目:
作者单位
吴 晋 南京医科大学第二附属医院神经内科,江苏 南京 210011 
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中文摘要:
      目的:探讨抗心磷脂抗体(ACA)?D-二聚体(D-Dimer)与急性脑梗死(ACI)的关系?方法:应用酶联免疫吸附试验(ELISA)对187例急性脑梗死患者清晨空腹血清中ACA?D-Dimer的含量进行检测,并与135例正常健康人群进行比较?结果:急性脑梗死组的ACA阳性率远较正常对照组高,差异显著(P < 0.01);ACA阳性组D-Dimer含量显著高于ACA阴性组;脑梗死患者病情越重,血清IgG-ACA阳性率越高,D-Dimer含量也越高;随时间变化,ACA阳性率逐渐减少,第1周与第2?第3?第4周ACA相比较(P < 0.01);ACA阳性与50岁(含50岁)以下脑梗死患者关系密切?结论:血清中ACA?D-Dimer动态变化对急性脑梗死的预后判断有一定帮助?
英文摘要:
      Objective:To explore relationship between anti-cardiolipin antibodies(ACA)?D-Dimer and acute cerebral infarction. Methods:The content of ACA?D-Dimer in blood serum of 187 acute cerebral infarction patients was detected in the morning after fasting over night using ELISA methods, and compared with 135 average healthy cases. Results:The ACA positive rate in acute cerebral infarction group was much higher than control and the difference was statistically significant(P < 0.01); The content of D-Dimer in ACA-positive group was significantly higher than that in ACA-negative group; As the cerebral infarction worsenly, the IgG-ACA positive rate became higher as well as the content of D-Dimer; ACA in the 1st,2nd,3rd and 4th week were compared, suggesting that ACA positive rate reduced as time changed(P < 0.01); ACA positive status was closely related with cerebral infarction patients who were 50 years old or younger. Conclusion:The dynamic changes of ACA?D-Dimer in blood serum might be helpful in predicting prognosis of acute cerebral infarction.
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