文章摘要
陈 佳,王 建,束永前,刘 平.紫杉醇或奥沙利铂为主化疗方案治疗晚期胃癌的临床观察[J].南京医科大学学报,2008,28(12):1602~1605
紫杉醇或奥沙利铂为主化疗方案治疗晚期胃癌的临床观察
A clinical study of paclitaxel-based or oxaliplatin-based regimens in the treatment of advanced gastric cancer
投稿时间:2008-08-10  
DOI:10.7655
中文关键词: 晚期胃癌  紫杉醇  奥沙利铂  化学治疗
英文关键词: advanced gastric cancinoma  paclitaxel  oxaliplatin  chemotherapy
基金项目:江苏省科技厅社会发展重点项目(BS2007011)
作者单位
陈 佳 南京医科大学第一附属医院肿瘤中心,江苏 南京 210029 
王 建  
束永前  
刘 平  
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中文摘要:
      目的:比较含紫杉醇或奥沙利铂的联合化疗方案一线治疗晚期胃癌的近期疗效?远期疗效及不良反应,并对两类方案的安全性进行评价?方法:84例晚期胃癌患者分为A?B两组,A组44例,采用紫杉醇联合氟脲嘧啶及顺铂的化疗方案;B组40例,采用奥沙利铂联合氟尿嘧啶的化疗方案?两组患者接受化疗均至少2周期,每2周期评判一次治疗效果?结果:A组客观有效率?疾病控制率?中位疾病进展时间?中位生存期?1年生存率分别为50%?84.1%?7.0个月?11.2个月和34.2%;B组分别为50%?75%?6.5个月?10.8个月和33.6%?A?B两组间比较,在客观有效率与生存期方面无显著性差异(P > 0.05)?A组主要不良反应为血液学毒性和脱发,B组主要不良反应为外周神经毒性?结论:以紫杉醇或奥沙利铂为主的联合化疗方案治疗晚期胃癌,均有较好近期和远期疗效,两种方案疗效无显著差异,不良反应的特点有差别,但均可耐受,可根据患者个体的状况选择应用?
英文摘要:
      Objective:To compare the efficacy,toxicity and safety of paclitaxel-based or oxaliplatin-based regimens in the treatment of patients with advanced gastric cancer. Methods:Eighty-four patients with advanced gastric cancinoma were divided into 2 groups. Forty-four patients enrolled in group A were given paclitaxel-cisplatin-fluorouracil triplet regimen and 40 patients in group B received oxaliplatin-fluorouracil couplet regimen. Each patient received chemotherapy for at least 2 cycles and was evaluated every 2 cycles. Results:Objective results in the Group A showed:ORR 50%,DCR 84.1%, mTTP 7.0 months,mOS 11.2 months,one-year survival 34.2% and in Group B were:ORR 50%,DCR 75%,mTTP 6.5 months,mOS 10.8 months,one-year survival 33.6%. There was no significant difference in ORR,DCR,mTTP,mOS and 1-year survival(P > 0.05) between two groups. The main toxicity in group A was bone marrow depression and alopecia. The main toxicity in group B was neurotoxicity. Conclusion:Both paclitaxel-based regimen and oxaliplatin-based regimen showed comparable and good efficacy in the treatment of advanced gastric cancinomas. The toxicities caused by the two regimens were mild and tolerable,respectively.
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