文章摘要
黄剑飞,朱惠君,倪启超.三磷酸腺苷法肿瘤药敏试验在乳腺癌中的临床应用[J].南京医科大学学报,2008,28(12):1606~
三磷酸腺苷法肿瘤药敏试验在乳腺癌中的临床应用
Adenosine triphosphate based tumour chemosensitivity assay in breast carcinoma of clinical research
投稿时间:2008-04-08  
DOI:10.7655
中文关键词: 三磷酸腺苷法  肿瘤药物敏感  乳腺癌  个体化化疗
英文关键词: adenosine triphosphate based tumour chemosensitivity assay  tumour chemosensitivity  breast carcinoma  chemotherapy of individualization
基金项目:
作者单位
黄剑飞 南通大学附属医院病理科,江苏 南通 226001 
朱惠君 南通大学附属医院病理科,江苏 南通 226001 
倪启超 南通大学附属医院普外科,江苏 南通 226001 
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中文摘要:
      目的:采用三磷酸腺苷法肿瘤药敏试验(ATP-TCA)对乳腺癌组织标本进行试验,为个体化化疗选择提供客观依据?方法:75例乳腺癌新鲜标本行原代培养后,6种化疗药物用该方法进行试验?结果:所有标本均顺利完成试验,单药强敏感率顺序为THP(25.33%)?E-ADM(21.33%)?DTX(20.00%)?MTX(13.33%)?gemcitabine(12.00%),5-Fu(6.67%)?不同乳腺癌不但对同一种化疗药物的敏感度有明显差异(P < 0.05),而且对不同药物的敏感程度也具有统计学差异(P < 0.05)?随访3年可见,治疗组复发转移率低于对照组,也具统计学差异(P < 0.05)?结论:三磷酸腺苷法可方便有效检测乳腺癌个体的敏感化疗药物,在临床应用可提高乳腺癌化疗效果,为乳腺癌的临床个体化化疗提供重要的客观指导作用?
英文摘要:
      Objective:To investigate the heterogeneity of chemosensitivity in breast carcinoma using adenosine triphosphate based tumour chemosensitivity assay(ATP-TCA) and the feasibility of individual chemotherapy. Methods:ATP-TCA was used to determine the effect of 6 single drugs in surgical specimens from 75 patients with breast carcinoma. And 60 patients with breast carcinoma were used as matched control group. Results:All above these specimens were detected successfully. The sensitivity of six drugs was 25.33% for THP,21.33% for E-ADM,20.00% for DTX,13.33% for MTX,12.00% for gemcitabine,6.67% for 5-Fu in these specimens respectively. There were the heterogeneity of the in vitro chemosensitivity in breast carcinoma and had statistical significance(P < 0.05). After three years followed up,the relapse rate of therapy group was lower than that of the matched control group with statistical significance(P < 0.05). Conclusion:The use of the ATP-TCA may provide a method of selecting appropriate anti-cancer drugs of breast carcinoma in chemotherapy of individualization.
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