文章摘要
谢 敏,胡春洪,张追阳,蔡 颖,唐 威.胃癌CT分期以及CT强化与肿瘤血管生成关系研究[J].南京医科大学学报,2008,28(12):1621~1624
胃癌CT分期以及CT强化与肿瘤血管生成关系研究
Study on relationship between CT staging and CT enhancement of gastric cancer and tumor angiogenesis
投稿时间:2008-07-19  
DOI:10.7655
中文关键词: 胃肿瘤  X线计算机  分期  新生血管化  病理性
英文关键词: tumor of stomach  X-ray computer  staging  neo vascularization  pathologic
基金项目:
作者单位
谢 敏 南京医科大学附属无锡二院影像科,江苏 无锡 214002 
胡春洪 苏州大学附属第一医院影像科,江苏 苏州 215007 
张追阳 南京医科大学附属无锡二院影像科,江苏 无锡 214002 
蔡 颖 南京医科大学附属无锡二院病理科,江苏 无锡 214002 
唐 威 南京医科大学附属无锡二院病理科,江苏 无锡 214002 
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中文摘要:
      目的:研究胃癌CT分期?CT强化表现与肿瘤血管生成关系,为临床治疗提供有用信息?方法:30例经手术和病理证实为胃癌的患者术前予腹部螺旋CT双期增强扫描,测定胃癌病变研究区域的CT强化值,术后采集这30例患者胃癌标本,对相应研究部位进行二步法CD34单克隆抗体和VEGF单克隆抗体免疫组化染色,并依据临床?CT?病理结果对其病变进行TNM分期以及CT分期,将CT强化值?CT分期?TNM分期?病理分级结果以及CD34?VEGF染色结果进行统计学研究?结果:30例患者胃癌TNM分期与CT分期符合率为90%,CT强化值与TNM分期?CT分期呈明显正相关?CT强化值与微血管密度(MVD)呈正直线相关,方程式Y = 49.4125+0.5067X?VEGF高表达组与低表达组的CT强化值之间差异显著(P < 0.05),病理分级与CT强化值之间无相关关系(P > 0.05)?结论:依据CT表现可对胃癌进行术前分期,CT强化值可反映胃癌肿瘤血管的生成,CT强化值高低对胃癌病理分级无直接帮助?
英文摘要:
      Objective:To study the relationship between CT Staging and CT enhancement of gastric cancer and tumor angiogenesis and provide useful information for clinic therapy. Methods:Enhanced two-stage spiral CT scanning was given before operation to 30 cases who suffered from gastric cancer and were confirmed pathologically after operation. The 30 cases include 24 men and 6 women (average age was 63). CT enhancement values of pathologic region were determined. Tumor specimens of 30 cases were collected after operation. Two-step CD 34 mono-clone antibody and VEGF mono-clone antibody immunological and histo-chemical staining were performed on corresponding research area. TNM and CT staging were also performed based on clinical,CT and pathological findings. Statistical research was carried out on CT enhancement values,CT staging,TNM staging,pathological grading and results of CD 34 and VEGF staining. Results:Conformity rate of TNM staging and CT staging of 30 cases of gastric cancer was 90%. CT enhancement value was positively correlated with TNM and CT staging. CT enhancement value was positively linearly correlated with MVD. Its equation was Y = 49.4125+0.5067X. Difference of CT enhancement values between VEGF high and low expression groups was significant(P < 0.05). There was no relation between pathological grading and CT enhancement value(P > 0.05). Conclusion:Staging can be made by CT presentation before operation. CT enhancement value can reflect tumor angiogenesis of gastric cancer. Pathological grading has no direct assistance in the study of CT enhancement value.
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