文章摘要
陆宗海,林 琳,陈 蕾.肿瘤坏死因子α-308基因多态性与溃疡性结肠炎易感性的荟萃分析[J].南京医科大学学报,2008,28(12):1684~1689
肿瘤坏死因子α-308基因多态性与溃疡性结肠炎易感性的荟萃分析
Effect of the promoter polymorphism of tumor necrosis factor alpha 308 G/A gene on the susceptibility to ulcerative colitis:A meta-analysis
投稿时间:2008-05-25  
DOI:10.7655
中文关键词: 溃疡性结肠炎  肿瘤坏死因子  多态性  易感性  荟萃分析
英文关键词: ulcerative colitis  tumor necrosis factor  polymorphism  susceptibility  meta-analysis
基金项目:
作者单位
陆宗海 南京医科大学第一附属医院消化科,江苏 南京 210029 
林 琳  
陈 蕾  
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中文摘要:
      目的:运用荟萃分析方法综合评价肿瘤坏死因子α基因启动子308位(TNF-α-308)G/A基因型与溃疡性结肠炎(UC)的相关性?方法:检索PubMed?EMBase?CNKI和万方数据库,获取TNF-α-308基因多态性与溃疡性结肠炎易感性的病例-对照研究,使用统一的表格提取数据,应用Review Manager 4.2软件进行统计学处理?结果:检索文献中纳入14个病例-对照研究,其中欧洲8篇,美洲2篇,亚洲4篇(东亚3篇)?不按种族分层时,等位基因TNF2与UC易感性无相关性(OR1.32,95% CI 0.84~2.07,P = 0.22),按种族分层时,东亚人群等位基因TNF2与UC密切相关(OR 3.12,95% CI 1.44~6.77,P = 0.004),欧洲人群等位基因TNF2与UC易感性无相关性(OR 0.73,95% CI 0.41~1.31,P = 0.30),基因型(TNF2/1+TNF2/)vs TNF1/1者的UC易感性与等位基因TNF2者相似?结论:在东亚人群中TNF2等位基因是UC的危险因素,在欧洲人群中TNF-α-308的G/A基因多态性与UC无关?
英文摘要:
      Objective:To investigate the association between the polymorphism of tumor necrosis factor alpha 308 gene(TNF-α-308) promoter and the risk of ulcerative colitis(UC) using the method of meta-analysis. Method:The database of PubMed, EMBase, and CNKI(Chinese), Wanfang(Chinese) were searched for published case-control studies of the association between the polymorphism of TNF-α-308 gene promoter and UC. Data were extracted using a standardized form and the meta-analysis was performed. Results:Fourteen eligible studies, 8 of Europeans, 2 of Americans, and 4 of Asians including 3 East Asians, were included in the meta-analysis. However, stratification by ethnicity indicated that there was significant association between TNF2 allele and UC in East Asians(OR=3.12, 95% CI 1.44~6.77,P = 0.004). Conversely, there was no association between TNF2 allele and UC patients from the European(OR 0.73,95% CI 0.41~1.31,P = 0.30). The OR for the TNF2/2+TNF2/1 genotype verse TNF1/1 genotype in samples overall and in each ethnic group showed a similar trend to those for the TNF2 allele. Conclusion:In East Asians, the TNF2 allele confers a significant risk for developing UC. There is no association between the polymorphism of TNF-α-308 gene promoter and UC in Europeans.
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