文章摘要
李 杰,潘 昱,吴绥生.高血压病合并心律失常患者脂联素与脑钠肽相关[J].南京医科大学学报,2009,29(2):215~217
高血压病合并心律失常患者脂联素与脑钠肽相关
Circulating adiponectin in relation to brain natriuretic peptide in hypertensive subjects with arrhythmia subjects
投稿时间:2008-09-09  
DOI:10.7655
中文关键词: 高血压病  心律失常  脂联素
英文关键词: hypertension  arrhythmia  adiponectin
基金项目:吉林省卫生厅基金资助(9731)
作者单位
李 杰 吉林大学第一医院老年病学科,吉林 长春 130021 
潘 昱 首都医科大学附属安贞医院心血管科,北京 
吴绥生 吉林大学第一医院老年病学科,吉林 长春 130021 
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中文摘要:
      目的:探讨高血压病及高血压合并心律失常患者血清脂联素水平,及其与脑钠肽(BNP)?C-反应蛋白(CRP)的相关性?方法:选取原发性高血压病患者71例,分为单纯高血压组(36例)及合并心律失常组(35例)?测定血清脂联素?BNP?CRP水平,并进行相关性分析?结果:合并心律失常组[(0.977 ± 0.340)mg/L]及单纯高血压病组[(1.977 ± 0.990)mg/L]脂联素浓度显著低于正常对照组[(6.451 ± 1.972)mg/L](P < 0.01),合并心律失常组脂联素浓度显著低于单纯高血压组(P < 0.01)?合并心律失常组及单纯高血压组BNP?CRP浓度高于正常对照组,合并心律失常组BNP?CRP浓度显著高于单纯高血压组(P < 0.01)?单纯高血压组及合并心律失常组血清脂联素与BNP?CRP均呈负相关?结论:高血压病患者,血清脂联素降低?CRP及BNP水平升高,合并心律失常的高血压患者上述指标改变更为显著?血清脂联素与血清BNP?CRP呈负相关?脂联素可能与高血压病发生?发展有关?
英文摘要:
      Objective:To study the significance of variance in plasma adiponectin(APN) in hypertensive patients with arrhythmia, and the relationship between plasma APN and brain natriuretic peptide(BNP), c-reactive protein(CRP). Methods:The study comprised 71 hypertensive subjects who were divided into 2 groups, 35 of whom were hypertension with arrhythmia, the other were simplex hypertensive subjects. The plasma APN, BNP and CRP were determined. The relationship between them were tested. Results: Plasma APN levels significantly decreased in both hypertension with arrhythmia group[(0.977 ± 0.340)mg/L] and simplex hypertensive subjects[(1.977 ± 0.990)mg/L] than that in control[(6.451 ± 1.972)mg/L]. APN levels in hypertension with arrhythmia group significantly decreased than that in simplex hypertensive subjects. Whereas plasma BNP and CRP levels significantly increased in both hypertension with arrhythmia group and simplex hypertensive subjects. BNP and CRP levels in hypertension with arrhythmia group significantly decreased than that in simplex hypertensive subjects. In both hypertension with arrhythmia group and simplex hypertensive subjects, plasma adiponectin levels negatively correlated with BNP and CRP. Conclusion:Plasma adiponectin decreased in simplex hypertensive subjects and BNP and CRP increased. The change was more significantly in hypertension with arrhythmia group. Plasma adiponectin negatively associated with BNP and CRP. Adiponectin may be related to the occurrence and development of hypentension.
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