溃克灵对溃疡性结肠炎模型大鼠血清IL-8含量的影响
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南京市卫生局医学科技重点课题资助(ZKX0135,ZKX07007)


Effects of kuikeling on IL-8 levels in the serum of rats with ulcerative colitis
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    摘要:

    目的:建立溃疡性结肠炎(UC)大鼠模型,研究溃克灵(KKL)对大鼠溃疡性结肠炎的治疗作用及对血清白细胞介素-8(IL-8)产生和表达的影响,探讨KKL防治溃疡性结肠炎的作用机制-方法:采用2,4,6一三硝基苯磺酸(TNBS)法(100 mg/kg TNBS + 50%的乙醇0.25 ml)灌肠复制出溃疡性结肠炎大鼠模型-将72只大鼠随机分为正常组-模型组-柳氮磺吡啶(SASP)组-KKL大-中-小剂量组,观察结肠大体形态损伤-组织学变化,ELISA法测定各组大鼠血清IL-8水平-结果:与模型组相比,KKL各组-SASP组结肠大体形态损伤-组织学变化显著改善,血清IL-8水平显著降低(P < 0.01)-结论:溃克灵对大鼠UC有显著的治疗作用,抑制促炎因子IL-8的产生和表达可能是其治疗机制之一-

    Abstract:

    Objective:To study the effects of Kuikeling(KKL) on IL-8 levels in the serum of rats with ulcerative colitis and to research them mechanism for repairing these ulcers. Methods:Ulcerative colitis model was established by TNBS method. Total of 72 rats were randomly divided into 6 groups:normal group,model group,KKL large, medium,and little dose groups,SASP group. Colon mucosal inflammation and damage were assessed by mucosal lesion area and histological damage scores. Levels of serum interleukin-8(IL-8) were detected by ELISA. Results:Compared with the model group,the Mucosal lesionarea and histological damage scores in treatment groups were significantly improved, and the serum levels of IL-8 in the of treatment group were significantly decreased(P < 0.01). Conclusion:The present study proved that KKL has therapeutic effect on UC,it can down-regulate the serum levels of IL-8.

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周红光,陈海彬,徐肇敏,于成功.溃克灵对溃疡性结肠炎模型大鼠血清IL-8含量的影响[J].南京医科大学学报(自然科学版),2009,29(4):488-490

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  • 收稿日期:2008-10-31
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