Objective:To investigate the turnover of hepatic tissue pathology,hepatitis B reactivation rate in chronic HBV carriers. Methods:A 5-year dynamic observation and research on 220 chronic HBV carriers in WuXi district has been taken via viewing the clinical symptoms,histology,virology and HBV immunological markers,et al. Results:There were differences in inflammation grade and fibrosis stage between HBeAg positive and anti-HBe positive group cases(Kruskal-Wallis Test,χ2 = 8.68,P = 0.0032. χ2 = 6.84,P = 0.0089),showing that the inflammation grade and fibrosis stage of the anti-HBe positive group was higher than that of the HBeAg positive group. There were no obvious differences in the inflammation grade between age < 40 years old and ≥40 years old group cases(χ2 = 0.62,P > 0.05),but significant statistical differences in the fibrosis stage(χ2 = 7.37,P < 0.01),showing the fibrosis stage of the ≥40 years old group cases was clearly higher than the < 40 years old group cases. 35 of 220 patients,accounting for 15.9%,showed hepatitis B reactivation. The hepatitis B reactivation rate of patients with obvious hepatic tissue inflammation(≥ G2)was 27%(33/122)and the patients with mild hepatic tissue inflammation(G0-G1) was 2%(2/98),showing a significant differences(χ2 = 25.41,P < 0.01) and the reactivation rate of patients with high inflammation was clearly higher than those with mild inflammation. 27 of 35 hepatitis B reactivation cases were older than 40 years,showing the significant statistical differences between the dissimilar age group cases and hepatitis B reactivation rate(χ2 = 6.72,P < 0.01),moreover there was no relation between the sex and hepatitis B reactivation rate. 56 cases received liver biopsy for the second time and 23 for the third time. We find that those whose pathology of hepatic tissue was normal kept stable for several years while abnormal ones hardly recovered or achieved light change. Conclusion:The hepatic tissue pathology for most chronic HBV carriers(55%) had significant abnormality(inflammation grade ≥ G2),and hepatitis B reactivation corresponded to the liver inflammation grade(G) and dissimilar age group.