文章摘要
陆志斌,陈亦江,吴延虎,陈 亮.心房组织中5-HT4受体亚型mRNA的变化与房颤发生与维持[J].南京医科大学学报,2009,29(5):678~681
心房组织中5-HT4受体亚型mRNA的变化与房颤发生与维持
Relationship between the mRNA expression of serotonin 5-HT4 receptor isoforms and atriaI fibrillation in atrial myocardium
投稿时间:2008-12-30  
DOI:10.7655
中文关键词: 房颤  房间隔  5-HT4受体亚型
英文关键词: atrial fibrillation  interatrial septum  serotonin 5-HT4 receptor isoforms
基金项目:
作者单位
陆志斌 南京医科大学第一附属医院心胸外科,江苏 南京 210029 
陈亦江  
吴延虎  
陈 亮  
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中文摘要:
      目的:探讨房颤患者房间隔5-HT4受体4种亚型(5-HT4Ra?5-HT4Rb?5-HT4Rg?5-HT4Ri)mRNA的表达及其临床意义?方法:将行瓣膜置换手术的患者36例,分为窦性心律(SR)组和房颤(AF)组?术中取房间隔组织,采用SYBR Green实时荧光定量PCR检测各组中5-HT4受体亚型mRNA的表达?结果:5-HT4Ra mRNA在SR组和AF组中的表达水平分别为(19.89 ± 9.68) × 10-4和(336.86 ± 255.56) × 10-4,AF组比SR组增加了1 593.61%(P < 0.01);5-HT4Rb mRNA在SR组和AF组中的表达水平分别为(23.32 ± 8.37) × 10-4 和(240.32 ± 242.49) × 10-4,AF组比SR组增加了930.53%(P < 0.01);5-HT4Rg mRNA在SR组和AF组中的表达水平分别为(2.23 ± 0.77) × 10-4和(0.72 ± 0.45) × 10-4,AF组比SR组减少了67.71%(P < 0.01);5-HT4Ri mRNA在SR组和AF组中的表达水平分别为(34.95 ± 8.08) × 10-4和(392.15 ± 347.75) × 10-4,AF组比SR组增加了1 022.03%(P < 0.01)?结论:5-HT4受体亚型mRNA表达的变化可能在房颤的发生和维持中发挥一定的作用?
英文摘要:
      Objective:To investigate the mRNA expression of four serotonin 5-HT4 receptor isoforms(5-HT4Ra,5-HT4Rb,5-HT4Rg,5-HT4Ri) in interatrial septum with atrial fibrillation(AF) and study its clinic significance. Methods:Interatrial septums were obtained from 36 patients who underwent heart valve replacement. Among them,17 patients were in sinus rhythm and 19 patients had AF. The mRNA expression of 5-HT4 receptor isoforms was measured by SYBR Green Real-time fluorescence quantitative PCR. Results:5-HT4Ra mRNA expression in the SR and AF Group was(19.89 ± 9.68) × 10-4 and(336.86 ± 255.56) × 10-4 respectively. Compared with the SR Group,it was increased by 1593.61%(P < 0.01) in the AF group;5-HT4Rb mRNA expression in the SR and AF Group was(23.32 ± 8.37) × 10-4 and(240.32 ± 242.49) × 10-4 respectively. And it was increased by 930.53%(P < 0.01) in the AF group;5-HT4Rg mRNA expression in the SR and AF Group was(2.23 ± 0.77) × 10-4 and(0.72 ± 0.45) × 10-4 respectively. But it was decreased by 67.71%(P < 0.01) in the AF group;5-HT4Ri mRNA expression in the SR and AF Group was(34.95 ± 8.08) × 10-4 and(392.15 ± 347.75) × 10-4 respectively. And it was increased by 1022.03%(P < 0.01) in the AF group. Conclusion:These data support that the abnormal mRNA expression of 5-HT4 receptor isoforms in interatrial septum may be involved in the occurrence and maintenance of AF.
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