心房组织中5-HT4受体亚型mRNA的变化与房颤发生与维持
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Relationship between the mRNA expression of serotonin 5-HT4 receptor isoforms and atriaI fibrillation in atrial myocardium
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    摘要:

    目的:探讨房颤患者房间隔5-HT4受体4种亚型(5-HT4Ra-5-HT4Rb-5-HT4Rg-5-HT4Ri)mRNA的表达及其临床意义-方法:将行瓣膜置换手术的患者36例,分为窦性心律(SR)组和房颤(AF)组-术中取房间隔组织,采用SYBR Green实时荧光定量PCR检测各组中5-HT4受体亚型mRNA的表达-结果:5-HT4Ra mRNA在SR组和AF组中的表达水平分别为(19.89 ± 9.68) × 10-4和(336.86 ± 255.56) × 10-4,AF组比SR组增加了1 593.61%(P < 0.01);5-HT4Rb mRNA在SR组和AF组中的表达水平分别为(23.32 ± 8.37) × 10-4 和(240.32 ± 242.49) × 10-4,AF组比SR组增加了930.53%(P < 0.01);5-HT4Rg mRNA在SR组和AF组中的表达水平分别为(2.23 ± 0.77) × 10-4和(0.72 ± 0.45) × 10-4,AF组比SR组减少了67.71%(P < 0.01);5-HT4Ri mRNA在SR组和AF组中的表达水平分别为(34.95 ± 8.08) × 10-4和(392.15 ± 347.75) × 10-4,AF组比SR组增加了1 022.03%(P < 0.01)-结论:5-HT4受体亚型mRNA表达的变化可能在房颤的发生和维持中发挥一定的作用-

    Abstract:

    Objective:To investigate the mRNA expression of four serotonin 5-HT4 receptor isoforms(5-HT4Ra,5-HT4Rb,5-HT4Rg,5-HT4Ri) in interatrial septum with atrial fibrillation(AF) and study its clinic significance. Methods:Interatrial septums were obtained from 36 patients who underwent heart valve replacement. Among them,17 patients were in sinus rhythm and 19 patients had AF. The mRNA expression of 5-HT4 receptor isoforms was measured by SYBR Green Real-time fluorescence quantitative PCR. Results:5-HT4Ra mRNA expression in the SR and AF Group was(19.89 ± 9.68) × 10-4 and(336.86 ± 255.56) × 10-4 respectively. Compared with the SR Group,it was increased by 1593.61%(P < 0.01) in the AF group;5-HT4Rb mRNA expression in the SR and AF Group was(23.32 ± 8.37) × 10-4 and(240.32 ± 242.49) × 10-4 respectively. And it was increased by 930.53%(P < 0.01) in the AF group;5-HT4Rg mRNA expression in the SR and AF Group was(2.23 ± 0.77) × 10-4 and(0.72 ± 0.45) × 10-4 respectively. But it was decreased by 67.71%(P < 0.01) in the AF group;5-HT4Ri mRNA expression in the SR and AF Group was(34.95 ± 8.08) × 10-4 and(392.15 ± 347.75) × 10-4 respectively. And it was increased by 1022.03%(P < 0.01) in the AF group. Conclusion:These data support that the abnormal mRNA expression of 5-HT4 receptor isoforms in interatrial septum may be involved in the occurrence and maintenance of AF.

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陆志斌,陈亦江,吴延虎,陈 亮.心房组织中5-HT4受体亚型mRNA的变化与房颤发生与维持[J].南京医科大学学报(自然科学版),2009,29(5):678-681

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  • 收稿日期:2008-12-30
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