文章摘要
孙 磊,杨志健,贾恩志.胱抑素C与冠心病的相关性研究[J].南京医科大学学报,2009,29(5):702~
胱抑素C与冠心病的相关性研究
Association of cystatin C and coronary heart disease
投稿时间:2008-11-29  
DOI:10.7655
中文关键词: 胱抑素  冠状动脉疾病  冠状动脉造影
英文关键词: cystatin C  coronary disease  coronary angiography
基金项目:
作者单位
孙 磊 南京医科大学第一附属医院心内科,江苏 南京 210029 
杨志健  
贾恩志  
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中文摘要:
      目的:研究血清胱抑素C(Cys C)与冠心病的相关性?方法:回顾性分析525例高度怀疑冠心病而行冠脉造影患者的临床资料,从冠心病病情程度?冠脉病变支数和冠脉病变Gensini总积分3方面研究血清Cys C水平与冠心病之间的关系?应用免疫比浊法检测血清Cys C浓度,对Cys C水平与冠心病病情?冠脉病变程度和冠脉病变Gensini总积分进行单因素和多因分析?结果:①随着血清Cys C水平的升高,冠心病患者病情逐渐加重,冠脉病变支数和Gensini总积分增加;在急性心梗时由于急性时相反应血清Cys C水平出现下降;②Logistic回归结果显示Cys C与冠脉有无病变显著相关(OR值5.346,95% CI为2.225~12.846,P < 0.01);③多元逐步回归结果显示在校正了年龄?性别等因素之后,Cys C与冠脉病变Gensini总积分(β = 0.149,P < 0.01)仍然独立相关?结论:血清Cys C水平与冠心病有密切关系?随着血清Cys C水平升高,冠心病患者病情逐渐加重,冠脉病变程度也更加严重?
英文摘要:
      Objective:To investigate the relationship between serum levels of cystatin C and severity of coronary heart disease(CHD). Methods:Five hundred and twenty-five patients with CHD who underwent coronary angiography were selected in the study.The relationship between serum levels of cystatin C and the pathogenetic condition of CHD,the number of diseased vessels and the CHD Gensini cumulative index was evaluated. Serum levels of cystatin C was measured by nephelometric immunoassay. All data were analyzed by univariate and multivariate analyses. Results:①With the increase of serum levels of cystatin C,the pathogenetic condition in patients with CHD became more serious,the number of diseased vessels and the CHD Gensini cumulative index increased.Due to the reaction at the acute phase of acute myocardial infarction(AMI),the serum levels of cystatin C decreased;②Further logistic regression analysis indicated that cystatin C had significant correlation with pathological changes of coronary artery(OR was 5.346,95% CI = 2.225~12.846,P < 0.01);③After adjusting the influencing factors such as age,sex and so on,multivariable stepwise regression analysis showed that cystatin C also had significant correlation with the CHD Gensini cumulative index(β = 0.149,P < 0.01). Conclusion:The serum levels of cystatin C had significant correlations with CHD.With the increase of serum levels of cystatin C,the pathogenetic condition and pathological changes of coronary artery in patients with CHD became more and more serious.
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