文章摘要
周 丹,陈晓晖,郭金和,何仕诚,闵 捷,滕皋军.肝癌的动态CT灌注成像具有可重复性[J].南京医科大学学报,2009,29(5):715~720
肝癌的动态CT灌注成像具有可重复性
Reproducibility of multi-slice CT perfusion imaging for liver cancer
投稿时间:2009-01-09  
DOI:10.7655
中文关键词: 灌注  肝癌  可重复性  体层摄影术  X线计算机
英文关键词: perfusion  liver cancer  reproducibility  computed tomography  X-Ray
基金项目:
作者单位
周 丹 东南大学临床医学院,江苏 南京 210009 
陈晓晖 东南大学临床医学院,江苏 南京 210009 
郭金和 东南大学临床医学院,江苏 南京 210009 
何仕诚 东南大学临床医学院,江苏 南京 210009 
闵 捷 东南大学公共卫生学院,江苏 南京 210009 
滕皋军 东南大学临床医学院,江苏 南京 210009 
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中文摘要:
      目的:研究肝癌的动态CT灌注成像(CTP)的可重复性?方法:采用德国Siemens sensation 64层螺旋CT机,应用Body PCT肝脏灌注软件进行处理,该软件应用的数学模型是斜率法和Patlak分析法?首先建立一个相对一致的标准后处理方法,应用软件处理后得到灌注彩图,用鼠标划出各感兴趣区,包括按肿瘤大小和按肿瘤直径一半划出的兴趣区(ROI)?然后建立1个后处理对比的方法,观察观测者之内的可重复性:2个技能和经验都不相同的观测者(甲?乙)采用双盲法分别进行(CTP)的后处理?分别对甲和乙的前后2次后处理的结果进行统计学分析,评价其前后2次后处理的一致性;观察观测者之间的可重复性:对甲和乙后处理分析的数据进行比较,评价不同操作人员对CTP可重复性的影响?结果:在第1次后处理时,甲乙2人有一致性;甲前后2次后处理有一致性;乙前后2次后处理也有一致性?结论:肝癌的动态CT灌注成像具有可重复性?
英文摘要:
      Objective:To evaluate the reproducibility of dynamic CT perfusion(CTP)imaging for liver cancer. Methods:Multi-slice spiral CT(Siemens sensation 64,Germany)was used and the data was processed with liver perfusion software-Body PCT,for which the mathematical model of slope and the analysis method of Patlak was used. First,a relative coincident and standard post-processing method was established. CT perfusion image was obtained after software processing,and each ROI was marked out with mouse,including the size of the tumor and the half-diameter ROI of the tumor. Then a post-processing method for comparison was built up:①To observe the reproducibility of the same operator:The operators who have different skills and experience(A and B)separately made the post-processing of CTP. The post-processing results from the same operator were statistically analyzed and the consistency was evaluated. ②To observe the reproducibility between the two operators:The results from the two operators were compared to evaluate the effects of different operators on the reproducibility of CTP. Results:The result from operator A was consistent with that from B for the first time; and there was also a good consistency between the results from the same operator. Conclusion:Dynamic CT perfusion imaging in liver cancer is a reproducible method.
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