文章摘要
陆海英,黄松明,张爱华,郑 帼,黄艳军.白细胞介素-1α-889C/T多态性与小儿癫痫易感性的关系[J].南京医科大学学报,2009,29(8):1153~1156
白细胞介素-1α-889C/T多态性与小儿癫痫易感性的关系
Association of IL-1α-889C/T polymorphism with the risk of pediatric epilepsy
投稿时间:2009-03-31  
DOI:10.7655
中文关键词: 小儿癫痫  Interleukin-1α基因  多态性  PCR-RFLP
英文关键词: pediatric epilepsy  interleukin-1α gene  polymorphism  PCR-RFLP
基金项目:南京医科大学科技发展基金项目(07NMUM078)
作者单位
陆海英 南京医科大学附属南京儿童医院儿内科,南京 210008 
黄松明  
张爱华  
郑 帼  
黄艳军  
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中文摘要:
      目的:探讨白细胞介素-1α-889C/T多态性与小儿癫痫易感性关系?方法:采用病例对照研究,选择117例小儿癫痫患者和95例健康儿童,应用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)进行IL-1α-889C/T多态性检测,比较不同基因型与小儿癫痫风险的关系?结果:与携带-889 CC基因型者比较,携带至少1个-889 T等位基因者(即CT和TT基因型)小儿癫痫风险增加2.91倍(95%CI = 1.27~6.69),且有癫痫或热性惊厥家族史者,-889突变型使小儿癫痫风险增加6.83倍(95% CI = 2.30~20.29)?结论:IL-1α-889C/T多态性可能与小儿癫痫遗传易感性有关,并可显著增加家族史对小儿癫痫的危险性?
英文摘要:
      Objective:To explore the relationship between IL-1α-889C/T polymorphism and the susceptibility to pediatric epilepsy. Methods:IL-1α-889C/T polymorphism in 117 patients with pediatric epilepsy and 95 healthy individuals controls were analyzed with polymerase chain reaction restriction and fragment length polymorphism(PCR-RFLP). Results:Multivariate Logistic regression analysis revealed that individuals carrying at least one -889 T variant allele (CT + TT genotypes) had a significant increased risk for pediatric epilepsy (adjusted OR = 2.91,95% CI:1.27~6.69) , compared with the wild-type genotype (-889CC) . Furthermore, individuals with epilepsy or febrile seizures family history had a significantly higher risk (adjusted OR = 6.83, 95% CI: 2.30~20.29), compared with those with both CC genotypes. Conclusion:These findings support the hypothesis that IL-1α-889C/T polymorphism may contribute to the risk of developing pediatric epilepsy.
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