Objective:To observe the effects of early intensive statin therapy on inflammatory factors and prognosis in patients with acute coronary syndrome(ACS). Methods:Total 70 patients with ACS were randomly divided into two groups:group A contained 35 patients administered with 10 mg/d atorvastatin besides of routine treatment,group B contained 35 patients administered with 40 mg/d atorvastatin besides of routine treatment. Before and after the treatment for one week,the plasma levels of inflammatory factors (hs-CRP,SAA,MMP-9,Fib) and blood lipid(TC,TG,LDL-C,HDL-C) were detected. All the patients were followed up for 60 days,and the incidence of cardiovascular disease and the adverse reaction of drug were detected. Results:Blood lipid levels had no significant changes in the two groups after treatment for one week(P > 0. 05). Except Fib,the inflammatory factors of hs-CRP,SAA and MMP-9 decreased significantly in group A after treatment with atorvastatin for one week(P < 0.05),and all the four inflammatory factors decreased significantly in group B(P < 0.05),and the changes were more significant in group B than that in group A (P < 0.05). The incidence of cardiovascular disease in group B was less than that in group A markedly (P < 0.05). No severe adverse effects were found in two groups. Conclusion:Early intensive statin therapy could reduce the levels of inflammatory factors,promote the stabilization of atherosclerotic plaque,reduce the incidence of cardiovascular disease and significantly improve prognosis of patients with ACS. Early intensive statin therapy has good effects and safety for patients with ACS.