文章摘要
吴〓静,徐〓建,张映铭,王彩英.干扰素诱导蛋白10对结核性胸膜炎的诊断价值[J].南京医科大学学报,2009,29(10):1432~1434
干扰素诱导蛋白10对结核性胸膜炎的诊断价值
The significance of detecting interferon-inducible protein 10 in the pleural effusion for diagnosis of tuberculous pleurisy
投稿时间:2009-05-11  
DOI:10.7655
中文关键词: 结核性胸膜炎  干扰素诱导蛋白10  γ-干扰素
英文关键词: tuberculous pleurisy  interferon-inducible protein 10  interferon-γ
基金项目:江苏省现代病原生物学重点实验室开放课题(08bykf06)
作者单位
吴〓静 南京市胸科医院呼吸科,江苏 南京〓210029 
徐〓建 南京医科大学第一附属医院医学检验科,江苏省现代病原生物学重点实验室,江苏 南京〓210029 
张映铭 南京市胸科医院呼吸科,江苏 南京〓210029 
王彩英 南京市胸科医院呼吸科,江苏 南京〓210029 
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中文摘要:
      目的:研究胸水中干扰素诱导蛋白10(interferon-inducible protein 10,IP-10)水平对结核性胸膜炎的诊断价值?方法:用ELISA 检测 43 例结核性胸膜炎和33例恶性胸腔积液患者胸水中IP-10水平;绘制受试者工作特征曲线(receiver operating characteristic curve,ROC 曲线)确定其诊断结核性胸膜炎的临界值,并评价其敏感性?特异性和诊断效能?结果:结核性胸膜炎组胸水中 IP-10 含量为(1 095.67 ± 556.29) pg/ml,显著高于恶性胸腔积液组(121.39±61.21) pg/ml,P < 0.01?IP-10 诊断结核性胸膜炎的临界值为194.5 pg/ml,敏感性和特异性分别为83.7%和97.0%;IP-10的诊断效能与γ-干扰素(IFN-γ)相近?结论:胸水中IP-10水平测定有助于结核性胸膜炎的诊断?
英文摘要:
      Objective:To evaluate the significance of interferon-inducible protein 10 (IP-10) level in the pleural effusion for the diagnosis of tuberculous pleurisy. Methods:Enzyme-linked immunosorbent assay (ELISA) was adopted to detect the level of IP-10 in 43 patients with tuberculous pleurisy and 33 patients with pleural effusion associated with malignant tumor. The receiver operating characteristic (ROC) curves were used to determine the cut-off value and assess the sensitivity,specificity and diagnostic efficiency. Results:The concentration of IP-10 was significantly higher in tuberculous pleurisy (1 095.67 ± 556.29 pg/ml) than in malignant pleurisy (121.39±61.21 pg/ml),(P < 0.01). When 194.5 pg/ml was used as cut-off value,the sensitivity and specificity for IP-10 in diagnosis of tuberculous pleurisy were 83.7% and 97.0%,respectively. And the diagnostic efficiency of IP-10 was similar to that of IFN-γ. Conclusion:Detection of IP-10 in the pleural effusion is helpful in the diagnosis of tuberculous pleurisy.
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