Objective:To observe the efficacy and security of Hemabate in prevention and cure of postpartum hemorrhage after cesarean section(CS) on parturient with hepatitis B. Methods: Three hundred cases of parturients with hepatitis B accepted cesarean section,whose liver function were abnormal but blood clotting function normal,were divided into 3 groups randomly,and named Hemabate group,Oxytocin group and Combined group respectively. They were all medicated at the moment after childbirth. The postpartum hemorrhage volumes in 2 hours and 24 hours,the ratios of postpartum hemorrhage and the total effective rates were compared among the 3 groups. The advise reactions and the changes of liver function including alanine aminotransferase(ALT),aspartate aminotransferase(AST),totle bilirubin(TB) after medication were observed. Results:The ratios of postpartum hemorrhage in uterine inertia of Hemabate group and Combined group were 22% and 20%,much lower than that of Oxytocin group (54%)(P < 0.01). The postpartum hemorrhage in Hemabate group volumes in 2 hours and 24 hours were (271.54±73.96)ml and (360.97±90.12)ml,which were both much lower than those in Oxytocin group(P < 0.01). The total effective rates of Hemabate group and combined group were 96%,which was higher than that of Oxytocin group (87%). The levels of ALT,AST,TB in Oxytocin group were higher than Hemabate group and combined group in different extent and there were significant differences in ALT and AST(P < 0.05),but there was no significant differentce in ALT,AST and TB between Hemabate group and Combined group(P > 0.05). Some patients suffered from nausea,vomiting,diarrhea,high blood pressure,etc., may almost recover without any disposal. Conclusion:The Hemabate has notable efficacy and slide adverse reaction in prevention and cure of postpartum hemorrhage after CS because of weak uterine contraction on parturient with hepatitis B. Further more,it had nearly no influence on liver function and had good security.