Objective:To investigate the left ventricular rotation in patients with atrial septal defect (ASD) after transcatheter closure of ASD. Methods:Using speckle tracking imaging(STI),the rotation of 6 segments of basal and apical short-axises were measured repeatedly in 25 patients with ASD before and after closure. 25 healthy subjects were included as controls. The global rotation of the 6 segments in basal and apical short-axises versus time profile were drawn,and the peak rotation of basal and apical short-axises were calculated. LV ejection fraction(EF)was measured by biplane Simpson method. Results:Compared with healthy subjects,the peak rotation of antsept wall,laterior wall,posterior wall,inferior wall and postsept wall in basal of ASD group were lower(P < 0.05). There was no significant difference between two groups on the peak rotation. LV rotation of apical short-axise increased after close, but was still lower than that of control group(P > 0.05). Conclusion:Transcatheter closure of ASD could increase rotation of basal short-axises,and also improve LV twist.