Protective effects of ulinastatin(UTI) on the brain of hypertensive cerebral hemorrhage used during operation
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摘要:
目的:研究高血压脑出血围术期应用乌司他丁对神经元特异性烯醇化酶的影响和脑保护作用-方法:高血压脑出血发病7 h内的手术患者40例,随机分为乌司他丁组(A组)和对照组(B组)-测定两组术前和术后12-36 h血清神经元特异性烯醇化酶(neuron-specific enolase,NSE)的浓度及术前和术后第8天的格拉斯哥(glasgow coma scale,GCS)的评分-结果:术后12 h和36 h,A组NSE浓度明显低于B组,术后第8天A组GCS评分明显高于B 组-结论:高血压脑出血术中早期应用乌司他丁有利于神经保护-
Abstract:
Objective:To study clinical protectional effects of neuron-specific enolase(NSE) using Ulinastatin on the brain of hypertensive cerebral hemorrhage during perioperative. Methods:Forty patients with operation suffering hypertensive cerebral hemorrhage in 7 days were divided into two groups:group A(n=20) with Ulinastatin and group B(n=20) as control. ICP was monitored,and NSE plasma levels and the scores of GCS were measured before and after operation. Results:NSE plasma levels in group A were significantly lower than that in group B,and the scores of GCS in group A were significantly higher than that in group B. Conclution:Ulinastatin had clinical protective effects on the brain of hypertensive cerebral hemorrhage during perioperative.
