比格犬静滴羟基喜树碱脂质体的毒代动力学研究
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国家自然科学基金资助(30771831)


Toxicokinetic study on intravenous infused LHPLC(hydroxycamptothecin liposome)by beagle dog model
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    摘要:

    目的:研究抗癌药物羟基喜树碱(HCPT)新剂型羟基喜树碱脂质体(LHCPT)在Beagle犬体内的毒物代谢动力学,探讨该药物是否在血液中有蓄积作用-方法:采用HPLC-荧光检测法测定全血中LHCPT的浓度-结果:在第1天和连续给药第30天后Cmax和AUC值存在剂量相关性;药物半衰期t1/2不同剂量之间无显著变化(P > 0.05)-AUC-Cmax-t1/2值多次给药与单次给药后比较,同剂量下均未见显著提高(P > 0.05)-结论:LHCPT连续静脉给药后未见血液中有明显蓄积现象-

    Abstract:

    Objective:To study the toxicokinetics of LHCPT in Beagle dogs by intravenous infusion,and discuss the accumulative effects of LHCPT in blood. Methods:HPLC with fluorescence detection was used to analyze drug concentration in whole blood. Results:Cmax and AUC were increased in a dose-dependent manner both after 1st day and 30th day;and there was no statistical significance in t1/2 of different doses (P > 0.05). Compared with single administration with repetition,there were no obvious changes of AUC,Cmax and t1/2 of the same dose(P > 0.05). Conclusion:LHCPT has no significantly accumulative effects after successive intravenous administration.

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赵鸿雁,高〓蓉,陈文中,庄〓翌,程〓光,肖〓杭.比格犬静滴羟基喜树碱脂质体的毒代动力学研究[J].南京医科大学学报(自然科学版),2010,(1):117-120

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  • 收稿日期:2009-03-06
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