文章摘要
彭杰成,龙明智,章海燕,徐少华,姜〓海.BNP?MCP-1对不稳定型心绞痛近期预后判断的价值[J].南京医科大学学报,2010,(3):405~408
BNP?MCP-1对不稳定型心绞痛近期预后判断的价值
The value of plasma BNP and MCP-1 levels for short-term prognosis of UA without heart failure
  
DOI:10.7655
中文关键词: UA  BNP  MCP-1  预后
英文关键词: unstable angina(UA)  brain natriuretic peptide(BNP)  monocyte chemoattractant protein-1(MCP-1)  prognosis
基金项目:江苏省"六大高峰人才"基金资助项目(2006075)
作者单位
彭杰成 南京医科大学第二附属医院心血管科,江苏 南京〓210011 
龙明智  
章海燕  
徐少华  
姜〓海  
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中文摘要:
      目的:探讨血浆B型钠尿肽(brain natriuretic peptide,BNP)?单核细胞趋化蛋白-1(monocyte chemoattractant protein-1,MCP-1)水平对不稳定型心绞痛(unstable angina,UA)近期预后判断的价值?方法:按Braunwald标准,85例心功能正常的UA患者分为ⅠB组(25例)?ⅡB组(30例)及ⅢB组(30例),并取20例稳定型心绞痛(SAP)患者作为对照组?入院后24 h内抽肘前静脉血,分别行BNP和MCP-1检测?随访30天内主要不良心脏事件(MACE)?结果:UA组BNP及MCP-1均显著高于对照组(P均< 0.05);ⅢB组显著高于ⅠB组和ⅡB组(P均< 0.05)?冠状动脉3支与2支病变组BNP明显高于单支病变组(P均< 0.05);3支病变组MCP-1明显高于2支及单支病变组(P均< 0.05)?Logistic回归分析显示BNP和MCP-1是30天MACE的独立预测因素?结论:血浆BNP?MCP-1水平对心功能正常的UA近期不良预后的评估具有重要意义?
英文摘要:
      Objective:To evaluate the early prognostic role of plasma brain natriuretic peptide(BNP)and monocyte chemoattractant protein-1(MCP-1)levels in patients with unstable angina(UA). Methods:Eighty-five cases UA without heart failure were divided into IB(n=25),IIB(n=30)and IIIB(n=30)groups according to Braunwald classification, and 20 cases stable angina pectoris(SAP)were chosen in the control group. Plasma samples for BNP and MCP-1 were obtained in the first 24 h. The incidences of main abnormal cardiac event(MACE)were recorded during 30 days. Results:In every UA groups,plasma levels of BNP and MCP-1 elevated significantly,and in comparison to those in the control group,there were statistically significant difference(all P < 0.05). Plasma levels of BNP and MCP-1 in IIIB group were higher than those in IIB group and IB group(all P < 0.05). The levels of BNP and MCP-1 were significantly higher in patients who had complex lesions compared with those who had simple lesions(P < 0.05). Multivariable logistic regression analysis revealed that BNP and MCP-1 were all risk factors for cardiac events(all P < 0.05). Conclusion:Measurement of BNP and MCP-1 are helpful in predicting the short-term prognosis in UA patients without heart failure.
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