文章摘要
潘〓彬,陆〓叶,陆〓明,朱〓江.PSA?F/T值与PSAD在前列腺穿刺活检中诊断价值的探讨[J].南京医科大学学报,2010,(4):514~517
PSA?F/T值与PSAD在前列腺穿刺活检中诊断价值的探讨
Rediscussion of diagnositic value of PSA,F/T ratio and PSAD in prostate biopsy
投稿时间:2009-11-20  
DOI:10.7655
中文关键词: 前列腺癌  前列腺特异性抗原  前列腺特异性抗原密度
英文关键词: prostate cancer  prostate specific antigen  prostate specific antigen density
基金项目:上海市宝山区科委基金资助(05-E-2)
作者单位
潘〓彬 南通市第一人民医院泌尿外科,江苏 南通〓226001 
陆〓叶 上海交通大学附属第一人民医院泌尿外科,上海〓200080 
陆〓明 南通市第一人民医院泌尿外科,江苏 南通〓226001 
朱〓江 上海交通大学附属第一人民医院泌尿外科,上海〓200080 
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中文摘要:
      目的:探讨前列腺特异抗原(PSA)?游离PSA/总PSA(F/T)比值及前列腺特异抗原密度(PSAD)在前列腺穿刺活检中的诊断价值?方法:选取2006年1月~2008年12月经直肠超声引导下前列腺穿刺活检患者285例,检测血清总PSA?游离PSA,计算F/T及PSAD,探讨穿刺诊断前列腺癌(PCa) 最佳的PSA?F/T值与PSAD值?结果:以PSA>15 ng/ml为临界值,PSA诊断前列腺癌的灵敏度为70.0%,特异度为68.5%,阳性预测值为58.6%;在PSA<15 ng/ml区域,良性前列腺增生(BPH)组与PCa组间PSA差别无显著性(t=0.018,P > 0.05),此时两组间F/T值及PSAD比较,差别均有显著统计学意义(t=4.137?3.158,P < 0.01)?F/T值取0.16,PSAD取0.35 ng/(ml·cm3)时,F/T值及PSAD诊断PCa的灵敏度?特异度?阳性预测值均较高?结论:PSA>15 ng/ml时高度怀疑前列腺癌;在PSA<15 ng/ml时联合应用F/T值和(或)PSAD可以明显提高前列腺癌的穿刺检出率?
英文摘要:
      Objective:To evaluate diagnositic value of prostate specific antigen (PSA),free/total PSA (F/T PSA),and PSA density (PSAD) in prostate biopsy. Methods:Total serum PSA and free PSA were detected while F/T PSA value and PSAD were calculated in 285 patients who underwent transrectal ultrasonography-guided prosate biopsy. Optimum PSA,F/T PSA value and PSAD for detecting Pca were discussed. Results:When the cut off value of PSA was set as>15 ng/ml,the diagnostic sensitivity,specificity and the positive predictive value were 70.0%,68.5% and 58.6% respectively. When PSA <15 ng/ml,the difference of PSA between BPA and Pca groups was not significant(t=0.018,P > 0.05),while F/T value and PSAD showed significant differences(t=4.137,3.158,P < 0.01). When the cue off value of F/T was set as 0.16 and the cue off value of PSAD as 0.35 ng/(ml·cm3),the sensitivity,specificity and the positive predictive values were higher. Conclusion:PCa should be highly suspected when PSA is more than 15 ng/ml. The detection rate of prostate cancer could be significantly improved in combination of F/T and/or PSAD.
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