文章摘要
卢正红,唐 伟,方小正.2型糖尿病静息心率与认知功能关系研究[J].南京医科大学学报,2010,(5):697~701
2型糖尿病静息心率与认知功能关系研究
Relationships between the resting heart rate and the cognitive function of patients with type 2 diabetes mellitus
  
DOI:10.7655
中文关键词: 心率  认知  糖尿病  2型
英文关键词: heart rate  cognition  diabetes mellitus  type 2
基金项目:
作者单位
卢正红 南京医科大学附属淮安第一医院老年科,江苏 淮安 223300 
唐 伟 南京医科大学第一附属医院内分泌科,江苏 南京 210029 
方小正 南京医科大学附属淮安第一医院老年科,江苏 淮安 223300 
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中文摘要:
      目的:研究2型糖尿病静息心率(RHR)与认知功能关系?方法:通过对140例2型糖尿病患者进行认知功能问卷调查,评定认知功能?将RHR分为<75次/min?≥75次/min且<85次/min及≥85次/min 3组,比较3组间认知功能差异?结果:3组间图片命名能力和简易智能状态量表(MMSE)中的即刻记忆能力?执行能力及语言能力差异有显著性(P < 0.05);3组在性别?年龄?教育年限和糖化血红蛋白(HbA1c)等方面无明显差异(P > 0.05),舒张压(DBP)?尿白蛋白/肌酐比值(UAIB/Cr)和超敏C-反应蛋白(HsCRP)在3组间差异有显著性(P < 0.05);RHR与MMSE总分?定向?语言等多个认知因子均呈负相关关系(P < 0.05;P < 0.01);UAIB/Cr和HsCRP组间RHR差异亦有显著性(P < 0.05)?结论:2型糖尿病RHR与认知功能密切相关;RHR增快时,可出现多个认知域损害?
英文摘要:
      Objective:To study the relationships between the resting heart rate(RHR) and the cognitive function of patients with type 2 diabetes mellitus (T2DM). Methods:Cognition was evaluated with questionnaires in 140 T2DM patients. The RHR was divided into three groups: <75 beats/min(bpm) group(65 cases),≥75 bpm and <85 bpm group(44 cases) and ≥85 bpm group(31 cases). The cognitive levels were compared among the three different RHR groups. Results:① There were significantly differences on the immediate memory of mini-mental state examination(MMSE) and naming picture,and the executive function and the linguistic capacity among the three groups(P < 0.05). ②It has no difference among the three groups in sex,age,the educational level,the duration of diabetes,combined hypertension or not,systolic blood pressure(SBP),hemoglobin A1c(HbA1c),cholesterol(TC),triglyeride(TG),high density lipoprotein(HDL-C),low density lipoprotein(LDL-C),lipoprotein(a) [LP(a)] and thyrotropic stimulating hormone(TSH) except diastolic blood pressure (DBP),the albumin/creatinine ratio in urine (UAIB/Cr) and the high sensitivity C-reactive protein (HsCRP). ③The RHR has negative corrections with the total score,orientation and linguistic capacity of MMSE,and naming picture,filling the lack of picture among the three groups (P < 0.05),and the executive function,composition of a picture and memory of MMSE(P < 0.01). ④There was a significant difference on RHR between UAIB/Cr <30 mg/g group and ≥30 mg/g,<300 mg/g group. And the RHR has prominent different between HsCRP ≥5 mg/L group and <5 mg/L group. Conclusion:The RHR has obvious correlation with cognitive function of patients with T2DM. RHR higher,damaged domains of cognition more.
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