Objective:To evaluate the treatment effect and recovering situation by indexes of cardiac structure,function and hemodynamics before and after ventricular septal defect occlusion using transthoracic echocardiography. Methods:Transthoracic echocardiography was performed in 38 patients with ventricular septal defect occlusion. Left atrial diameter(LAD),left ventricular end-diastolic and end-systolic diameter(LVDd/LVDs),left ventricular ejection fraction(LVEF),systolic peak flow velocity over left ventricular outflow tract(VLOVT)and diastolic peak velocity over mitral valve flow(Em/Am)were measured by conventional methods. Tissue doppler imaging on left ventricular wall was detected and peak systolic displacement(Ds),systolic peak velocity(Vs)were measured. Early diastolic peak velocity(E’),late diastolic peak velocity(A’)over mitral annulus and E’ over A’ ratio,Em over E’ ratio were calculated. Results:Early after transcatheter closure,LAD,LVDd and Ds were significantly reduced while VLOVT was increased obviously(P all <0.05). However,there was no significant difference in LVEF and Vs(P > 0.05). Em/E’ was also lower than that before the operation,but no significant difference. One year after occlusion,Em/E′returned to normal level from a high level,and the elevated VLOVT went back to the level before operation. Conclusion:In the early time after transcatheter closure,the patients’ cardiac structure and hemodynamics abnormalities which are caused by the left ventricular volume overload can be corrected. And in the inter-mediate stage after closure,the impaired left ventricular diastolic function can be improved. Echocardiography plays an important role in the evaluation of cardiac function before and after transcatheter closure.