文章摘要
张海鸣,徐三荣,周科军,焦志军,李〓梅.甲状腺激素对急性肝衰竭大鼠肝细胞的保护作用[J].南京医科大学学报,2010,(8):1112~1115
甲状腺激素对急性肝衰竭大鼠肝细胞的保护作用
Protective effect of thyroid hormone on the hepatocytes in a rat model of acute hepatic failure
投稿时间:2010-01-11  
DOI:10.7655
中文关键词: 甲状腺激素  急性肝衰竭  肝细胞  正常甲状腺病态综合征
英文关键词: thyroid hormone  acute hepatic failure  hepatocytes  euthyroid sick syndrome
基金项目:镇江市社会发展科技计划项目(SH2007021)
作者单位
张海鸣 江苏大学附属医院普外科,江苏 镇江〓212001 
徐三荣 江苏大学附属医院普外科,江苏 镇江〓212001 
周科军 江苏大学附属医院普外科,江苏 镇江〓212001 
焦志军 江苏大学附属医院普外科,江苏 镇江〓212001 
李〓梅 江苏大学附属医院普外科,江苏 镇江〓212001 
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中文摘要:
      目的:探讨补充外源性甲状腺激素对急性肝衰竭大鼠肝细胞的保护作用?方法:将SD大鼠36只随机分为3组:对照组?急性肝衰竭组和治疗组?利用D-半乳糖胺腹腔注射制作大鼠急性肝衰竭模型,观测是否存在正常甲状腺病态综合征;通过腹腔注入10 mg/L三碘甲状腺原氨酸(T3)1.5 ml/kg,以纠正肝衰竭大鼠的低T3状态,检测血清生化指标并用光镜观察肝细胞的变化和凋亡?结果:急性肝衰竭大鼠模型存在低T3状态,治疗组大鼠肝衰竭表现轻,48 h存活率显著高于急性肝衰竭组(P < 0.05)?急性肝衰竭组大鼠肝细胞明显变性坏死,而治疗组肝细胞受损程度较轻?结论:急性肝衰竭大鼠存在正常甲状腺病态综合征,补充外源性甲状腺激素可以改善急性肝衰竭预后,并且对急性肝衰竭时肝细胞有明显的保护作用?
英文摘要:
      Objective:To explore the protective effect of thyroid hormone supplement on the hepatocytes in a rat model of acute hepatic failure. Methods:Thirty-six SD rats were randomly distributed in three groups. In group-1(control group),the rats received only placebo. In group-2(AHF group),the rats received intraperitoneal injection of D-galactosamine and saline. In group-3(treatment group),the rats received intraperitoneal injection of triiodothyronine(T3)at a dose of 15 mg/kg in addition to D-galactosamine. Blood and liver samples were obtained in all animals for the determination of thyroid and hepatic function and assessment of hepatic injuries. Results:T3 was subnormal in rat model of acute hepatic failure. There were less hepatocyte injuries and lower mortality in the treatment group as compared to the AHF group(P < 0.05). Conclusion:A rat model of acute hepatic failure has euthyroid sick syndrome. Thyroid hormone supplement may improve the prognosis and have significant hepatocyte protection in this animal model of acute hepatic failure.
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