文章摘要
陈卫红,徐〓波,唐万琴,丛晓娜,罗鹏飞,曹〓尚,卫平民.莫西沙星治疗难治?复治?耐多药肺结核的Meta分析[J].南京医科大学学报,2010,(8):1166~1171
莫西沙星治疗难治?复治?耐多药肺结核的Meta分析
Meta-analysis of refractory,recurrent and multi-drug resistant tuberculosis treatment by moxifloxacin
投稿时间:2010-01-12  
DOI:10.7655
中文关键词: 结核病  肺结核  Meta分析
英文关键词: moxifloxacin  tuberculosis  Meta analysis
基金项目:江苏省科技厅资助项目(BK2009282)
作者单位
陈卫红 东南大学公共卫生学院流行病与卫生统计学系,江苏 南京〓210009 
徐〓波 东南大学公共卫生学院流行病与卫生统计学系,江苏 南京〓210009 
唐万琴 东南大学公共卫生学院流行病与卫生统计学系,江苏 南京〓210009 
丛晓娜 东南大学公共卫生学院流行病与卫生统计学系,江苏 南京〓210009 
罗鹏飞 东南大学公共卫生学院流行病与卫生统计学系,江苏 南京〓210009 
曹〓尚 东南大学公共卫生学院流行病与卫生统计学系,江苏 南京〓210009 
卫平民 东南大学公共卫生学院流行病与卫生统计学系,江苏 南京〓210009 
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中文摘要:
      目的:系统评价莫西沙星治疗难治?复治?耐多药肺结核的疗效和安全性?方法:纳入所有莫西沙星临床治疗难治?复治?耐多药肺结核的随机对照试验(randomized controlled trial,RCT),采用Cochrane协作网提供的RevMan 4.2进行数据分析?结果:共纳入9个RCT,Meta分析结果显示,莫西沙星治疗组与对照组相比,病灶吸收情况[OR=1.68,95%CI(1.14~2.49)]?痰菌转阴情况[OR=2.47,95%CI(1.61~3.79)]的差异均有显著性意义?不良反应主要有胃部不适?恶心?反酸?食欲下降等胃肠道反应及轻度的肝功能损害,经对症处理后恢复?结论:目前的有限证据表明,莫西沙星治疗难治?复治?耐多药肺结核,有助于病灶吸收及痰菌转阴,有一定的疗效?
英文摘要:
      Objective:To evaluate the efficacy and safety of moxifloxacin treatment on refractory,recurrent and multi-drug resistant tuberculosis. Methods:The randomized controlled trials of moxifloxacin which is used to treat the refractory,recurrent and multi-drug resistant tuberculosis were recruited. Data were analyzed using RevMan 4.2 provided by the Cochrane Center. Results:Nine RCTs were included. Meta analysis showed that compared with the control group,moxifloxacin was more effective in focus absorption[OR = 1.68,95% CI(1.14~2.49)]and sputum negative conversion[OR=2.47,95% CI(1.61~3.79)]. Adverse effect such as stomach discomfort,nausea,acid reflux,loss of appetite and other gastrointestinal reactions and mild liver dysfunction appeared,and recovered by symptomatic treatment. Conclusion:The current limited evidence suggests that the moxifloxacin treatment on refractory,recurrent and multi-drug resistant tuberculosis is useful for focus absorption and the sputum negative conversion.
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