文章摘要
马玉娟,欧阳建.99mTc-MDP骨显像对多发性骨髓瘤骨病的诊断价值[J].南京医科大学学报,2010,(8):1199~1202
99mTc-MDP骨显像对多发性骨髓瘤骨病的诊断价值
The clinical evaluation of bone scintigraphy in diagnosis of multiple myeloma bone disease
投稿时间:2010-01-21  
DOI:10.7655
中文关键词: 多发性骨髓瘤  99mTc-MDP显像  X线
英文关键词: multiple myeloma  99mTc-MDP scintigraphy  X-ray
基金项目:
作者单位
马玉娟 南京医科大学鼓楼临床医学院血液科,江苏 南京〓210008 
欧阳建 南京医科大学鼓楼临床医学院血液科,江苏 南京〓210008 
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中文摘要:
      目的:探讨99mTc-MDP骨显像对多发性骨髓瘤(multiple myeloma,MM)骨病的诊断价值?方法:回顾分析了83例初诊的MM患者,均行全身99mTc-MDP骨显像,以X线检查部位为限定范围,与相应部位的骨显像结果进行比较分析?结果:99mTc-MDP骨显像阳性率为88.0%(73/83例),X线检查阳性率为73.3%(55/75例),低于骨显像的阳性率,但同时行头颅?胸片?腰椎及骨盆X线检查患者的X线检查阳性率与骨显像检查无显著差异(P=0.726)?99mTc-MDP骨显像对肋骨病变的阳性率高于X 线(P < 0.01),X线对头颅?骨盆病灶阳性率高于骨显像(P < 0.01)?结论:99mTc-MDP骨显像与多部位的X线检查总的敏感性相似,但骨显像对肋骨病灶的敏感性优于X线,而X线则对检测头颅?骨盆病变更敏感,故两种检查方法相互结合,对不相符部位进一步行CT/MRI 验证是提高MM骨病检出率的重要途径?
英文摘要:
      Objective:To study the application of 99mTc-MDP bone scintigraphy in multiple myeloma(MM) bone disease. Methods:99mTc-MDP bone scintigraphy and skeletal radiography of 83 newly diagnosed MM patients were analyzed. Results:The positive rate of bone scintigraphy was 88.0%(73/83 cases),and X-ray had a positive rate of 73.3%(55/75 cases),lower than bone scintigraphy. But the positive rate of patients who had multi-site X-ray examination including chest,lumbar and pelvic,had no significant difference(P=0.726)from bone scintigraphy. The positive rate of 99mTc-MDP bone scintigraphy for rib lesions was higher than that of X-ray(P < 0.01). While the positive rate of X- ray for the skull,pelvic lesions was higher than that of bone scintigraphy(P < 0.01). Conclusion:99mTc-MDP bone scintigraphy and multi-site X-ray examination have the similar sensitivity. But scintigraphic images were more sensitive to rib lesions than radiography,while the X-ray was more sensitive in the detection of skull,pelvic lesions. Therefore,the combination of bone scintigraphy and X-ray has obvious benefit to diagnose multiple myeloma. When these two methods do not match each other,CT/MRI can be used to improve the detection rate of MM bone disease.
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