Objective:To compare the anti-infection efficacy of gatifloxacin and levofloxacin. If there is no statistical difference between the two treatment,the economic evaluation of the two drugs was compared. Methods:Meta analysis of literature (a total of 10 selected literature),which was in line with the inclusion criteria of gatifloxacin and levofloxacin in the treatment of acute bacterial infection,was processed with the rate of bacterial clearance after treatment,clinical efficacy,clinical cure rate as an indicator,with the minimum cost method for economic evaluation of drugs. Results:The two drugs on the treatment of bacterial infections was no significant difference. The minimum cost method showed that gatifloxacin had a higher cost than levofloxacin. Conclusion:Gatifloxacin and levofloxacin have same efficacy in the treatment of bacterial infections. But the pharmacoeconomics value of levofloxacin is better than gatifloxacin.