文章摘要
王东苗,吴煜农.谷胱甘肽S转移酶T1基因多态性与口腔癌易感性的meta分析[J].南京医科大学学报,2010,(10):1413~1416
谷胱甘肽S转移酶T1基因多态性与口腔癌易感性的meta分析
Association between GSTT1 gene polymorphisms and risk of oral cancer:a meta analysis
投稿时间:2010-06-12  
DOI:10.7655
中文关键词: 口腔癌  谷胱甘肽S转移酶T1基因  基因多态性  Meta分析
英文关键词: oral cancer  GSTT1  race  gene polymorphisms  meta analysis
基金项目:江苏省卫生厅2010年度招标立项课题(Z201008)
作者单位
王东苗 南京医科大学附属口腔医院,口腔医学研究所,江苏 南京 210029 
吴煜农 南京医科大学附属口腔医院,口腔医学研究所,江苏 南京 210029 
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中文摘要:
      目的:通过既往相关研究,综合评价谷胱甘肽S转移酶T1(glutathione S-transferase class Theta-1,GSTT1)基因多态性与口腔癌易感性间的关联?方法:根据系统评价的原理和规范,检索PubMed数据库,纳入GSTT1基因与口腔癌的病例对照研究?根据种族,采用分层Meta分析评估GSTT1基因多态性与口腔癌的关联性,同时评估发表偏倚?结果:Meta分析显示,GSTT1基因多态性与口腔癌总的效应为OR=1.17(95%CI:0.87~1.58)?进一步亚组分析显示,亚洲人种OR=0.99 (95%CI:0.71~1.36);高加索人种OR=1.07 (95%CI:0.69~1.64);混合人种OR=1.89 (95%CI:0.76~4.67)?结论:尚不能认为GSTT1基因多态性能影响口腔癌的易感性,这一结论尚需要大规模?多种族的流行病学或功能学研究验证?
英文摘要:
      Objective:To evaluate the relationship between glutathione S-transferase class Theta-1(GSTT1) gene polymorphisms and oral Cancer. Methods:According to the theory and principles of systematic review,data from case-control studies regarding the association between GSTT1 gene polymorphisms and oral cancer were derived through electronic search of PubMed. To gain a more precise estimation of the relationship,a stratified meta-analysis with three subgroups was performed according to the races. Publication bias was also assessed by chi-square based Q test. Results:The overall effect between GSTT1 gene polymorphisms and oral cancer was OR=1.17 (95%CI:0.87~1.58). Furthermore,subgroup analysis were performed according to race. However,no significant effect was found[OR=0.99 (95%CI:0.71~1.36)in Asian;OR=1.07 (95%CI:0.69~1.64)in Caucasian;OR=1.89(95%CI:0.76~4.67)in Mixed race]. Conclusion:The association between GSTT1 gene polymorphisms and oral cancer was negative,and further large scale and multi-race epidemiological or biological functional studies were warranted to evaluate the results.
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