文章摘要
程 剑,施启丰.胃癌中C-erbB-2?Ki-67的表达及其意义[J].南京医科大学学报,2010,(11):1612~1614
胃癌中C-erbB-2?Ki-67的表达及其意义
Expression and significance of C-erbB-2 and Ki-67 in gastric carcinoma
投稿时间:2010-05-14  
DOI:10.7655
中文关键词: C-erbB-2  Ki-67  胃癌  免疫组织化学
英文关键词: C-erbB-2  Ki-67  gastric carcinoma  immunohistochemistry
基金项目:
作者单位
程 剑 无锡卫生高等职业技术学校病理教研室,江苏 无锡 214028 
施启丰 无锡市锡山人民医院病理科,江苏 无锡 214011 
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中文摘要:
      目的: 研究C-erbB-2和Ki-67在胃癌中表达和意义?方法:采用免疫组化SP法检测77例原发性胃癌中C-erbB-2及Ki67的表达?结果:C-erbB-2在胃癌中的阳性率为62.3%,在胃炎中的阳性率为6.7%,两者有显著差异(P < 0.05)?C-erbB-2在胃癌中的表达与胃癌的浸润深度有关(P < 0.05),与胃癌患者的年龄?性别?胃癌的分化程度和淋巴结转移无关(P > 0.05)?Ki-67在胃癌中的阳性率为77.9%,在慢性胃炎阳性率为10.0%,两者有显著差异(P < 0.05)?Ki-67的表达与胃癌患者的年龄?性别?肿瘤的浸润深度?分化程度和淋巴结转移无关(P > 0.05)?结论:C-erbB-2?Ki-67的异常表达和胃癌的早期发生有关?
英文摘要:
      Objective: To study the expression and significance of C-erbB-2 and Ki67 in gastric carcinoma. Methods:The expression of C-erbB-2 and Ki67 were examined by SP immunohistochemical technique in 77 cases of primary gastric carcinoma samples. Results:The positive rates of C-erbB-2 in gastric carcinoma and gastritis cases were 62.3% and 6.7%, respectively, a significance existed between the two groups(P < 0.05). The expression rate of C-erbB-2 in gastric carcinoma was positively correlated with the invasion depth in gastric carcinoma(P < 0.05), and was not correlated with age, gender, differentiation and lymph node metastasis(P > 0.05). The positive rate of Ki67 in gastric carcinoma and gastritis cases were 77.9% and 10.0%, respectively, a significance was found between the two groups(P < 0.05). The positive rate of Ki67 in gastric carcinoma was not correlated with age, gender, invasion depth, differentiation and lymph node metastasis(P < 0.05). Conclusion:The over-expression of C-erbB-2 and Ki-67 may be involved in early stage of gastric carcinoma.
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