文章摘要
王 飞,王亚非,张 亮,印 滇.紫杉醇脂质体联合5-氟尿嘧啶?亚叶酸钙和顺铂治疗晚期胃癌的临床观察[J].南京医科大学学报,2010,(11):1653~1656
紫杉醇脂质体联合5-氟尿嘧啶?亚叶酸钙和顺铂治疗晚期胃癌的临床观察
Paclitaxel liposome combined with 5-Fu/CF and DDP in treatment of patients with advanced gastric cancer
投稿时间:2010-06-25  
DOI:10.7655
中文关键词: 紫杉醇脂质体  晚期胃癌  联合化疗
英文关键词: paclitaxel liposome  advanced gastric cancer  combined chemotherapy.
基金项目:
作者单位
王 飞 南通市第一人民医院肿瘤科,江苏 南通 226001 
王亚非 南通市第一人民医院肿瘤科,江苏 南通 226001 
张 亮 南通市第一人民医院肿瘤科,江苏 南通 226001 
印 滇 南通市第一人民医院肿瘤科,江苏 南通 226001 
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中文摘要:
      目的: 观察紫杉醇脂质体联合5-氟尿嘧啶(5-Fu)?亚叶酸钙(CF)和顺铂(DDP)治疗晚期胃癌的临床疗效和不良反应?方法:晚期胃腺癌患者56例随机分为实验组和对照组?实验组28例静脉滴注紫杉醇脂质体135 mg/m2(第1天),5-Fu500 mg/(m2·天)和CF200 mg/天(第1~5天),DDP 20 mg/m2(第2~5天);对照组以紫杉醇135 mg/m2代替紫杉醇脂质体,余同实验组?每21天为1个周期,每2个周期后评价疗效和不良反应?结果:实验组有效率(RR)46.4%,疾病控制率(DCR)78.5%,1年生存率39.1%;对照组RR 32.1%,DCR 50.0%,1年生存率17.8%?两组RR差异无统计学意义(P=0.274),DCR差异有统计学意义(P=0.026),1年生存率差异无统计学差异(P=0.138)?在不良反应方面,实验组在粒细胞减少(P=0.044)?恶心呕吐(P=0.015)及呼吸困难(P=0.036)方面优于对照组,且有统计学意义;其余不良反应相仿?结论:与紫杉醇相比,紫杉醇脂质体联合5-Fu?DDP治疗晚期胃癌具有良好疗效和耐受性?
英文摘要:
      Objective: To evaluate the efficacy and toxicity of paclitaxel liposome combined with 5-Fu/CF and DDP in treatment of patients with advanced gastric cancer. Methods:Fifty-six patients with advanced gastric cancer were divided into two groups randomly, the test group and the control group. The test group was treated with paclitaxel liposome 135 mg/m2 on day 1, 5-Fu 500 mg/m2 and CF 200 mg on day 1~5, DDP 20 mg/m2 on day 2~5. The control group was treated with paclitaxel 135 mg/m2 on day 1, 5-Fu 500 mg/m2 and CF 200mg on day 1~5, DDP 20 mg/m2 on day 2~5. The regimen was repeated every 21 days. All patients received at least for 2 cycles. Result: In the test group, the response rate(RR) and the disease controlled rate(DCR) were 46.4%, 78.5% respectively. One-year survival was 39.1%. In the control group, the RR, DCR and one-year survival were 32.1%, 50.0% and 17.8% respectively. The DCR in two groups had significant deviation. About adverse reactions, granulocytopenia, nausea, vomiting and allergy in the test group were decreased significantly compared with the control group. Conclusion: Paclitaxel liposome combined with 5-Fu, CF and DDP is active in patients with advanced gastric cancer and has less toxicity than paclitaxel.
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