胃肠道肿瘤患者腹内脂肪脂联素的表达及临床意义
DOI:
作者:
作者单位:

作者简介:

通讯作者:

中图分类号:

基金项目:

江苏省卫生厅重点科学基金(XK200701)


the expression level and clinical significance of adiponectin gene on abdomen adipocyte in the patients with gastroenteric tumor
Author:
Affiliation:

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    目的:探讨胃肠道肿瘤患者腹内脂肪组织中脂联素mrna的表达及其临床意义-方法:临床收集39例胃肠道肿瘤手术患者(其中转移组21例,未转移组18例)和20例非肿瘤正常对照组腹内脂肪;提取脂肪组织中总rna,采用real-time pcr技术检测脂联素的表达水平-结果:胃肠道肿瘤组脂肪组织脂联素水平较对照组降低,差异有统计学意义(p < 0.05),肿瘤转移组(3.85±1.41)较未转移组(4.90±1.06)脂联素表达水平降低,但差异无统计学意义(p > 0.05)-结论:脂肪组织脂联素表达水平降低与胃肠道肿瘤发生相关,为肿瘤治疗的新途径提供理论依据-

    Abstract:

    objective:to evaluate the expression level and clinical significance of adiponectin gene on abdomen adipocyte in the patients with gastrointestinal cancer. methods:the study included the samples from surgical patients who were mainly divided into two groups, the cancer group(n=39) and the control group(n=20). then the gastrointestinal cancer group contained the metastasic group (n=21) and the no-metastasic group(n=18). total rna were collected from adipocyte, and the expression level of adiponectin have been detected with real-time pcr. results:the expression level of adiponectin mrna in cancer group was significantly lower than control group(p < 0.05), and the expression level in the metastasic group(3.85±1.41) was lower than the no-metastasic group(4.90±1.06), but there was no significance(p > 0.05). conclusion:the expression level of abdomen adipocyte adiponectin gene may be involved in the gastrointestinal tumor generation, which can provide theoretical foundation for a new treatment.

    参考文献
    相似文献
    引证文献
引用本文

杨瑞雪,马向华,沈 捷.胃肠道肿瘤患者腹内脂肪脂联素的表达及临床意义[J].南京医科大学学报(自然科学版),2011,(4):454-456

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:2010-09-13
  • 最后修改日期:
  • 录用日期:
  • 在线发布日期:
  • 出版日期: