文章摘要
杨瑞雪,马向华,沈 捷.胃肠道肿瘤患者腹内脂肪脂联素的表达及临床意义[J].南京医科大学学报,2011,(4):454~456
胃肠道肿瘤患者腹内脂肪脂联素的表达及临床意义
the expression level and clinical significance of adiponectin gene on abdomen adipocyte in the patients with gastroenteric tumor
投稿时间:2010-09-13  
DOI:10.7655
中文关键词: 胃肠道肿瘤  脂联素  脂肪组织
英文关键词: gastrointestinal tumor  adiponectin  adipose tissue
基金项目:江苏省卫生厅重点科学基金(XK200701)
作者单位
杨瑞雪 南京医科大学第一附属医院内分泌科,江苏 南京 210029 
马向华 南京医科大学第一附属医院内分泌科,江苏 南京 210029 
沈 捷 南京医科大学第一附属医院内分泌科,江苏 南京 210029 
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中文摘要:
      目的:探讨胃肠道肿瘤患者腹内脂肪组织中脂联素mrna的表达及其临床意义?方法:临床收集39例胃肠道肿瘤手术患者(其中转移组21例,未转移组18例)和20例非肿瘤正常对照组腹内脂肪;提取脂肪组织中总rna,采用real-time pcr技术检测脂联素的表达水平?结果:胃肠道肿瘤组脂肪组织脂联素水平较对照组降低,差异有统计学意义(p < 0.05),肿瘤转移组(3.85±1.41)较未转移组(4.90±1.06)脂联素表达水平降低,但差异无统计学意义(p > 0.05)?结论:脂肪组织脂联素表达水平降低与胃肠道肿瘤发生相关,为肿瘤治疗的新途径提供理论依据?
英文摘要:
      objective:to evaluate the expression level and clinical significance of adiponectin gene on abdomen adipocyte in the patients with gastrointestinal cancer. methods:the study included the samples from surgical patients who were mainly divided into two groups, the cancer group(n=39) and the control group(n=20). then the gastrointestinal cancer group contained the metastasic group (n=21) and the no-metastasic group(n=18). total rna were collected from adipocyte, and the expression level of adiponectin have been detected with real-time pcr. results:the expression level of adiponectin mrna in cancer group was significantly lower than control group(p < 0.05), and the expression level in the metastasic group(3.85±1.41) was lower than the no-metastasic group(4.90±1.06), but there was no significance(p > 0.05). conclusion:the expression level of abdomen adipocyte adiponectin gene may be involved in the gastrointestinal tumor generation, which can provide theoretical foundation for a new treatment.
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