文章摘要
王 琛,姚维娜,马正良,顾小萍.大鼠切口痛模型中氯化锂对瑞芬太尼诱发痛觉过敏的影响[J].南京医科大学学报,2011,(4):495~499
大鼠切口痛模型中氯化锂对瑞芬太尼诱发痛觉过敏的影响
effects of lithium chloride on remifentanil-induced hyperalgesia in rat model of incisional pain
投稿时间:2010-08-10  
DOI:10.7655
中文关键词: 氯化锂  切口痛  瑞芬太尼  痛觉过敏
英文关键词: lithium chloride  incisional pain  remifentanil  hyperalgesia
基金项目:南京市卫生局重大课题(zkx08028)
作者单位
王 琛 南京医科大学鼓楼临床医学院麻醉科,江苏 南京 210008 
姚维娜 南京医科大学鼓楼临床医学院麻醉科,江苏 南京 210008 
马正良 南京医科大学鼓楼临床医学院麻醉科,江苏 南京 210008 
顾小萍 南京医科大学鼓楼临床医学院麻醉科,江苏 南京 210008 
摘要点击次数: 972
全文下载次数: 132
中文摘要:
      目的:在大鼠切口痛模型中,观察氯化锂对瑞芬太尼引起的痛觉过敏的影响?方法:42只sd雄性大鼠,随机分成7组:对照组(c组);切口痛组(i组);瑞芬太尼组(r组);切口痛+氯化锂组(il组);切口痛+瑞芬太尼+低浓度氯化锂组(rl1组);切口痛+瑞芬太尼+中等浓度氯化锂组(rl2组);切口痛+瑞芬太尼+高浓度氯化锂组(rl3组)?每组6只?il组给予氯化锂36 mg/kg体重;rl1?rl2?rl3组分别给予氯化锂9?18?36 mg/kg体重,均在七氟醚吸入前10 min腹腔注射,体积均为0.4 ml,而c?i?r组给予生理盐水0.4 ml?r组和各rl组均在七氟醚吸入后15 min在皮下以0.8 ml/h的速度泵入瑞芬太尼40 μg/kg体重,c?i?il组泵生理盐水?除c组外均做切口痛模型?各组均测定并计算出术前24 h(t0)?术后6 h(t1)?24 h(t2)?48 h(t3)大鼠右后爪的机械缩足反射阈值(pmw)及热缩足反射潜伏期(pwtl)?结果:在t1?t2?t3时点,与i组相比,r组的pmw和pwtl明显降低(p < 0.05)?与i组相比,il组能缓解pmw和pwtl的降低(p < 0.05)?与r组比,各rl组能明显缓解pmw和pwtl的降低(p < 0.05)?结论:在大鼠切口痛模型中,瑞芬太尼可以诱发切口周围组织的痛觉过敏;氯化锂可以提高切口痛的阈值并预防瑞芬太尼诱发的痛觉过敏?
英文摘要:
      objective:to observe the effects of lithium chloride(licl)pretreatment on remifentanil-induced hyperalgesia in rats model of incisional pain. methods:fourty-two male sprague dawley(sd) rats were randomly divided into seven groups(n=6):control group(c),incisional pain group(i),remifentanil+ incisional pain group(r),incisional pain+licl group(il),remifentanil+incisional pain+low-dose licl group(rl1),remifentanil+incisional pain+medium-dose licl group(rl2),remifentanil+incisional pain+high-dose licl group(rl3). licl 0.4 ml were administered to il group and rl1~3 groups intraperitoneally ten minutes before anesthesia with sevoflurane,the dose of licl in il group and rl1~3 groups were 36,9,18,36 mg/kg respectively,accordingly saline were administered intraperitoneally to group c,i and r. r group and rl1~3 groups were pumped subcutaneously with remifentanil(40 μg/kg)at the speed of 0.8 ml/h at fifteen minutes after anesthesia with sevoflurane,while group c,i and il were pumped subcutaneously with saline accordingly. all groups except c were made the model of incisional pain. at t0(24 hours before operation)and t1(6 hours after operation),t2(24 hours after operation),t3(48 h after operation)respectively,paw withdrawal thermal latency(pwtl) and paw mechanical withdrawal threshold(pmw) were detected on the rats’ right hindpaw in all groups. results:at t1,t2,t3,the pmw and pwtl were significantly lower in group r and significantly higher in group il then those in group i(p < 0.05). comparing with group r,the pmw and pwtl in rl groups were significantly higher(p < 0.05). conclusion:in rat model of incisional pain,remifentanil could induce hyperalgesia on the area of adjacent to the incision;lithium chloride could increase the pain threshold of incision and prevent the remifentanil-induced hyperalgesia.
查看全文   查看/发表评论  下载PDF阅读器
关闭