文章摘要
刘春兴,邹 健.糖尿病与肝外胆管癌发病关系的Meta分析[J].南京医科大学学报,2011,(6):834~837
糖尿病与肝外胆管癌发病关系的Meta分析
Association between diabetes mellitus and the risk of extrahepatic cholangiocarcinoma: a Meta-analysis
投稿时间:2010-12-13  
DOI:10.7655
中文关键词: 糖尿病  肝外胆管癌  病例对照研究  队列研究  Meta分析
英文关键词: diabetes mellitus  extrahepatic cholangiocarcinoma  case-control study  cohort study  Meta-analysis
基金项目:
作者单位
刘春兴 上海市华东疗养院检验科,江苏 无锡 214065 
邹 健 南京医科大学附属无锡市人民医院中心实验室,无锡市临床医学实验研究所,江苏 无锡 214023 
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中文摘要:
      目的:用Meta分析法探讨糖尿病是否增加肝外胆管癌发病风险?方法:利用中国学术期刊全文数据库?万方全文数据库及Medline,EMBASE数据库检索国内外公开发表的从建库至2010年9月的所有关于糖尿病与肝外胆管癌发病关系的中英文文献;利用随机效应模型计算纳入文献的合并RR值及其95%CI值;进行亚组分析以探究异质性来源并分析出版偏倚?结果:纳入分析的文献共7篇(病例对照研究4篇,队列研究3篇)?经Meta分析,与未患糖尿病者相比,糖尿病患者肝外胆管癌发病的风险增加,相对风险值分别为OR=1.62 (95%C1=1.05~2.49)(病例对照研究);RR=1.54(95%C1=1.06~2.23)(队列研究);亚组资料分析显示研究有显著异质性,但无明显发表偏倚(Egger检验,P = 0.798;Begg检验,P = 0.548)?结论:本研究提示糖尿病可能是肝外胆管癌的致病危险因素?
英文摘要:
      Objective:To explore the association between diabetes mellitus(DM) and risks of extrahepatic cholangiocarcinoma (ECC) by meta-analysis. Methods:Databases of Chinese CNKI, Wanfang, Medline, EMBASE were searched for the articles on the relationships of DM and ECC risk from databases establishment to September 2010;Adjusted relative risks(RRs) and their corresponding 95% confidence intervals(95%CI) were calculated using a random-effect model;Potential sources of heterogeneity between studies were explored and publication bias was evaluated. Results: DM was associated with an increased risk of ECC,with pooled OR=1.62(95%C1=1.05~2.49) for case-control studies and pooled RR=1.54(95%C1=1.06~2.23)for cohort studies. The significant heterogeneity was mitigated in some of the subgroup analyses and publication bias was not significantly in the studies(Egger’s test,P = 0.798;Begg’s test,P = 0.548). Conclusion: The present study suggests that DM may be a high risk factor for ECC.
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