文章摘要
吴清泉,赵 铭,陈其友,黄建峰.手术治疗局限期小细胞肺癌患者的多因素预后分析[J].南京医科大学学报,2011,(7):1032~1035
手术治疗局限期小细胞肺癌患者的多因素预后分析
The multivariate analysis of prognosis in limited small cell lung cancer patients who underwent surgery
投稿时间:2011-01-09  
DOI:10.7655
中文关键词: 小细胞肺癌  手术  预后
英文关键词: small cell lung cancer  surgical treatment  prognosis
基金项目:南京医科大学科技发展基金面上项目(2010NJMU017)
作者单位
吴清泉 南京医科大学附属淮安第一医院胸外科,江苏 淮安 223300 
赵 铭 南京医科大学附属淮安第一医院胸外科,江苏 淮安 223300 
陈其友 南京医科大学附属淮安第一医院胸外科,江苏 淮安 223300 
黄建峰 南京医科大学附属肿瘤医院胸外科,江苏 南京 210009 
摘要点击次数: 1161
全文下载次数: 125
中文摘要:
      目的:探讨手术在局限期小细胞肺癌(SCLC)治疗中的作用,并分析影响其预后的因素,为小细胞肺癌手术治疗提供科学依据?方法:对本院1985年1月~2005年12月间收治的,且组织学病理以及影像学明确诊断为局限期小细胞肺癌的70例手术患者进行生存时间的分析,经Kaplan-Meier生存分析?Cox回归分析等方法,探讨影响小细胞肺癌手术疗效的相关预后因素? 结果:本组SCLC手术患者Ⅰ期?Ⅱ期以及Ⅲ期的5年生存率分别为63.8%?40.1%?33.2%?Cox单因素以及多因素分析表明:TNM分期?是否行化疗?手术方式和KPS评分是影响SCLC患者手术预后的独立危险因素?结论:以手术为主的治疗能使局限期SCLC患者受益,且TNM分期?是否行化疗?患者KPS评分是影响其预后的独立危险因素?
英文摘要:
      Objective:To explore the potential role of the surgical treatment in limited small cell lung cancer(SCLC) and analyze the factors affecting the prognosis. Methods:From January 1985 to December 2005, the survival rate of 70 in-patients with limited SCLC confirmed by histological pathology and imaging were analyzed. Furthermore, the related prognostic factors of patients underwent surgery were investigated by Kaplan-Meier estimator and Cox regression analysis. Results:The five-year survival rates of patients with stage Ⅰ,Ⅱ,Ⅲ SCLC were 63.8%, 40.1% and 33.2%, respectively. The Cox regression analysis indicated that TNM stage, application of platinum-based chemotherapy, operative manner and KPS scores were independent prognostic factors for SCLC patients after surgery. Conclusion: Patients with limited SCLC may benefit from the comprehensive treatment based on surgery. TNM stage, application of platinum-based chemotherapy, operative manner and KPS scores were independent prognostic factors for SCLC patients after surgery.
查看全文   查看/发表评论  下载PDF阅读器