文章摘要
项 斌,王芳军,刘鹏飞,孟宪平,朱建新.CT灌注成像技术在非酒精性脂肪肝的应用价值研究[J].南京医科大学学报,2011,(10):1506~1509
CT灌注成像技术在非酒精性脂肪肝的应用价值研究
Clinical application of 64-slice CT perfusion imaging on non-alcoholic fatty liver disease
投稿时间:2011-05-03  
DOI:10.7655
中文关键词: X线计算机体层摄影术  非酒精性脂肪性肝病  灌注
英文关键词: X-ray computed tomography  non-alcoholic fatty liver disease  perfusion
基金项目:
作者单位
项 斌 东南大学医学院附属江阴医院消化科,江苏 江阴 214400 
王芳军 东南大学医学院附属江阴医院消化科,江苏 江阴 214400 
刘鹏飞 东南大学医学院附属江阴医院消化科,江苏 江阴 214400 
孟宪平 东南大学医学院附属江阴医院放射科,江苏 江阴 214400 
朱建新 东南大学医学院附属江阴医院放射科,江苏 江阴 214400 
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中文摘要:
      目的:应用Philip Brilliance 64排螺旋CT,对非酒精性脂肪肝(NAFLD)患者行肝CT灌注成像,以观察CT灌注参数的变化,评估脂肪肝CT灌注参数与病情严重程度的关系,探讨CT灌注成像对NAFLD临床应用价值?方法:2009年10月~2010年6月,以20例健康人为对照,57例NAFLD患者行MSCT(多层螺旋CT)肝脏灌注成像,利用Philip Brilliance 64排螺旋CT自带软件perfusion CT 进行处理得到灌注参数:肝动脉灌注量(HAP)?门静脉灌注量(PvP)?总肝灌注量(TLP)?肝动脉指数(HPI)等?结果:NAFLD患者CT灌注门静脉灌注量(PvP)?总肝灌注量(TLP)均下降,HPI上升与对照组相比差异有统计学意义,且以中?重型NAFLD患者肝脏血流灌注异常为主?结论:NAFLD患者存在肝脏血流灌注异常,CT灌注成像技术可用于测定NAFLD患者肝脏血流灌注参数,CT灌注成像有望成为NAFLD患者病情评估的手段?
英文摘要:
      Objective: To research the blood perfusion characteristic of non-alcoholic fatty liver disease (NAFLD) using multisection dynamic CT. Methods: Dynamic 64-slice computed tomography scans of the liver were obtained in 72 individuals including 20 control subjects,52 patients with NAFLD from October 2009 to June 2010. The multisection dynamic CT perfusion series were performed by a multisection CT scanner (Philip Brilliance 64),120 kV,250 mAs. The data were processed on a Philip Brilliance 64 workstation using perfusion CT software package,and the mean HAP,PVP,TLP,and HPI were measured and statistically analyzed in 72 subjects. Results: Liver perfusion (TPL and PVP) in patients with NAFLD decreased (P < 0.05) and HPI increased significantly (P < 0.05). Conclusion: Hepatic perfusion parameters measured with CT were significantly altered in NAFLD. Dynamic 64-slice CT is potential in predicting prognosis of patients with NAFLD.
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