文章摘要
羊海涛,肖占沛,还锡萍,胡海洋,徐晓琴,李 雷,郭宏雄.江苏省HIV耐药警戒线的调查[J].南京医科大学学报,2012,(1):1~4
江苏省HIV耐药警戒线的调查
Threshold survey of transmitted HIV-1 drug resistance in Jiangsu province
投稿时间:2011-05-10  
DOI:10.7655
中文关键词: HIV-1  耐药警戒线  亚型
英文关键词: HIV-1  drug resistance threshold  subtype
基金项目:江苏省社会发展项目(BS2006078);江苏省自然科学基金(BK2009432)
作者单位
羊海涛 江苏省疾病预防控制中心性病艾滋病防治所,江苏 南京 210009 
肖占沛 东南大学公共卫生学院流行病学与卫生统计学系,江苏 南京 210009 
还锡萍 江苏省疾病预防控制中心性病艾滋病防治所,江苏 南京 210009 
胡海洋 江苏省疾病预防控制中心性病艾滋病防治所,江苏 南京 210009 
徐晓琴 江苏省疾病预防控制中心性病艾滋病防治所,江苏 南京 210009 
李 雷 江苏省疾病预防控制中心性病艾滋病防治所,江苏 南京 210009 
郭宏雄 江苏省疾病预防控制中心性病艾滋病防治所,江苏 南京 210009 
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中文摘要:
      目的:了解江苏省开展艾滋病抗病毒治疗以来,耐药毒株的传播情况和亚型分布?方法:通过横断面调查,采集17~25岁HIV-1感染者的全血样品,测定HIV-1pol区编码蛋白酶和逆转录酶基因的序列,提交到斯坦福大学HIV在线耐药数据库中鉴定耐药位点?用MEGA4.0软件构建进化树,分析亚型?结果:47份样品中,没有发现HIV-1的耐药株?共有CRF01_AE?B?CRF07_BC和CRF08_BC 4种亚型流行,CRF01_AE是主要流行的亚型,占59.6%,其次为B亚型,占25.5%?结论:江苏省还未发现耐药株的传播,个体治疗前尚不需要进行耐药性检测?在江苏省流行的HIV-1亚型与2006年相比,已经发生了显著变化,为掌握目前江苏省HIV-1的亚型分布,应对近2年发现的HIV感染者进行分子流行病学研究?
英文摘要:
      Objective: To survey the prevalence of HIV-1 drug resistance and subtype distribution among population with newly infected with HIV who were younger than 25 years of age and not received antiretroviral treatment. Methods:Blood specimens of HIV infected individuals were collected and HIV-1 pol gene was sequenced. The genetic mutations associated with drug resistance were identified with Stanford HIV Drug Resistance Database online. The phylogenetic tree was built with MEGA4.0 software,and subtypes were analyzed. Results: No mutations associated with HIV-l drug resistance was found in the reverse transcriptase and protease region. There are 4 subtypes,CRF01_AE,B,CRF07_BC and CRF08_BC,identified among 47 isolates. CRF01_AE was predominated,which account for 59.6%,followed by B subtype which reached to 25.5%. Conclusion: The first line regiments of national anti-retrovirus treatment is still effective. Testing drug resistance to HIV is not needed before starting anti-retroviral therapy(ART). Subtype distribution of HIV changed obviously compared with 2006. To further know dynamic HIV prevalence in Jiangsu province,the molecular epidemiology study on HIV-infected population confirmed within the past two years should be conducted.
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