STAT4基因rs7574865多态性与中国汉族人群克罗恩病的相关性
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江苏省医学重点学科开放课题资助项目(KF200936-6)


Association of the STAT4 gene rs7574865 polymorphism in the Chinese Han population with Crohn’s disease
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    摘要:

    目的:分析信号转导及转录激活因子4(signal transducer and activator of transcription 4,STAT4)基因单核苷酸多态性(single nucleotide polymorphism,SNP)位点rs7574865 G>T的多态性与中国汉族人群克罗恩病发生的相关性-方法:选取汉族克罗恩病患者318例与健康对照者318例作为研究对象,抽提基因组DNA,采用聚合酶链式反应和直接测序方法检测STAT4基因SNP位点rs7574865的基因型,计算基因型与基因频率,采用χ2检验进行组间比较-结果:STAT4基因rs7574865多态位点GG-GT和TT基因型频率在病例组中分别为0.110-0.431和0.459,在对照组中分别为0.097-0.450和0.453,G和T等位基因的频率在病例组分别为0.325和0.675,在对照组分别为0.322和0.678,该位点基因型和等位基因分布在病例组与对照组均无统计学差异(P > 0.05)-结论:STAT4基因rs7574865 G>T位点单核苷酸多态性与中国汉族人群克罗恩病发生无明显相关性-

    Abstract:

    Objective:To investigate the association of a single nucleotide polymorphism(SNP),rs7574865 G>T,of the signal transducer and activator of transcription 4 (STAT4) with Crohn’s disease(CD) in the Chinese Han population. Methods: Genomic DNA from 636 individuals of Chinese Han origin including 318 patients with CD and 318 healthy controls was analyzed for the SNP (rs7574865) of the STAT4 gene. SNP rs7574865 G>T was genotyped by polymerase chain reaction and direct sequencing. A Chi-square test was used to determine the association of SNP with CD. Results: The frequencies of genotypes GG,TG and TT at SNP rs7574865 G>T were 0.110,0.431 and 0.459 in CD patients,while 0.097,0.450 and 0.453 in healthy controls. The frequency of G or T allele was 0.325 or 0.675,respectively in CD patients,while 0.322 or 0.678 in healthy controls. Conclusion: These findings indicate that no significant difference is observed between STAT4 polymorphism and Crohn’s disease in the Chinese Han population.

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庞 智,郑连民,尹少朋,皇甫照,施瑞华. STAT4基因rs7574865多态性与中国汉族人群克罗恩病的相关性[J].南京医科大学学报(自然科学版),2012,(1):77-81

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  • 收稿日期:2011-04-06
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