| 张 肖,夏文颖,顾 兵,蔡 辉,严佳斌,张 杰,文 怡,潘世扬.血培养阳性病原菌种类及耐药性监测[J].南京医科大学学报,2012,(1):119~124 |
| 血培养阳性病原菌种类及耐药性监测 |
| Analysis of the types and resistance surveillance of pathogens isolated from blood culture |
| 投稿时间：2011-09-13 |
| DOI：10.7655 |
| 中文关键词: 血培养 病原菌 耐药性 |
| 英文关键词: blood culture pathogens resistance |
| 基金项目:国家自然科学基金项目(81000754);江苏省实验诊断学重点实验室重大课题(XK200731) |
| 作者 | 单位 | | 张 肖 | 南京医科大学第一附属医院医学检验科,江苏 南京 210029/江苏盛泽医院检验科,江苏 吴江 215228 | | 夏文颖 | 南京医科大学第一附属医院医学检验科,江苏 南京 210029 | | 顾 兵 | 南京医科大学第一附属医院医学检验科,江苏 南京 210029 | | 蔡 辉 | 江苏盛泽医院检验科,江苏 吴江 215228 | | 严佳斌 | 江苏盛泽医院检验科,江苏 吴江 215228 | | 张 杰 | 南京医科大学第一附属医院医学检验科,江苏 南京 210029/江苏盛泽医院检验科,江苏 吴江 215228 | | 文 怡 | 南京医科大学第一附属医院医学检验科,江苏 南京 210029 | | 潘世扬 | 南京医科大学第一附属医院医学检验科,江苏 南京 210029 |
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| 中文摘要: |
| 目的:监测南京医科大学第一附属医院2010年血培养阳性病原菌的耐药性,指导临床合理用药?方法:收集南京医科大学第一附属医院2010年3 625份血培养阳性病原菌鉴定结果;细菌及真菌鉴定采用API系统,细菌药物敏感性测定采用纸片扩散法,真菌药物敏感性测定采用Rosco纸片法,Whonet 5.5软件进行数据分析?结果:3 625例血培养标本中有419份阳性,革兰阳性细菌占57.8%,革兰阴性细菌占38.4%,真菌占3.8%?病原菌耐药性分析结果显示:葡萄球菌和肠球菌中均未发现对万古霉素和替考拉宁的耐药株;肠杆菌科细菌对碳青霉烯类抗菌药高度敏感;非发酵菌对多种抗菌药耐药率高?结论:血培养中检出的病原菌种类较多,对多种抗菌药物的耐药率较高,应引起重视? |
| 英文摘要: |
| Objective:To investigate resistance to pathogens isolated from blood culture of the First Affiliated Hospital of Nanjing Medical University in 2010,which can be used to guide clinical therapy. Methods: Total 3 625 blood culture samples were collected from this hospital in 2010. Bacteria and fungus were identified by API systems;bacterial drug sensitivity was determined by disk diffusion method;drug sensitivity of fungi were determined by Rosco method;and Whonet 5.5 software was used for data analysis. Results: Among the 3 625 blood culture samples,419 cases showed positive. Gram-positive bacteria accounted for 57.8%,Gram-negative bacteria accounted for 38.4%,and fungi accounted for 3.8%. The resistance analysis showed that there was no resistant strain to vancomycin and teicoplanin in Staphylococcus and Enterococcus. Enterobacteriaceae isolates were highly sensitive to carbapenem. Non-fermenting bacteria showed a relatively high resistance to many antimicrobial drugs. Conclusion: There are many different kinds of pathogens isolated from blood culture,which showed high resistance to many antimicrobial agents. |
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