文章摘要
宁魏青,吴 洁,浦丹华.不同类型冠心病中MCP-1变化的Meta分析[J].南京医科大学学报,2012,(1):136~140
不同类型冠心病中MCP-1变化的Meta分析
The significance of serum monocyte chemoattractant protein-1 concentrations in different types of coronary heart disease:a meta-analysis
投稿时间:2011-04-15  
DOI:10.7655
中文关键词: MCP-1  冠心病  Meta分析
英文关键词: MCP-1  coronary heart disease  meta-analysis
基金项目:科技部“十一五”课题(2008BAI57B04)
作者单位
宁魏青 南京医科大学第一附属医院妇保科,江苏 南京 210036 
吴 洁 南京医科大学第一附属医院妇保科,江苏 南京 210036 
浦丹华 南京医科大学第一附属医院妇保科,江苏 南京 210036 
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中文摘要:
      目的:探讨血清单核细胞趋化蛋白-1(monocyte chemoattractant protein-1,MCP-1)水平与冠心病的关系?方法:检索并筛检2010年12月31日前发表的MCP-1水平与冠心病关系的相关文献,利用Rev Man 4.2对各项研究结果进行异质性分析,选择适当的分析模型进行Meta分析?结果:共纳入13篇文献,稳定型心绞痛(stable angina,SA)396例?不稳定型心绞痛(unstable angina,UA)366例?急性心肌梗死(acute myocardial infarction,AMI) 268例及正常对照446例?Meta分析结果显示,SA?UA及AMI组患者血清MCP-1水平明显高于正常对照组 (P均 < 0.01)?SA组标准化均数差(standardized mean difference,SMD)=0.71,95%可信区间(confidential interval,CI):0.30~1.12;UA组SMD=1.98,95%CI:1.15~2.81;AMI组SMD=2.69,95%CI:1.67~3.70;UA组患者血清MCP-1水平较SA组患者高0.77~2.20倍标准差,AMI组较UA组患者高0.32~0.67倍标准差?结论:冠心病患者血清MCP-1水平明显升高,且MCP-1水平与冠心病的严重程度相关?
英文摘要:
      Objective: To evaluate the association between coronary heart disease(CHD) and serum concentration of monocyte chemoattractant protein-1(MCP-1). Methods: CNKI,WanFang,VIP and PubMed databases were searched,and the end time was December 31,2010. Statistical analysis was performed with the software program review manage,version 4.2. Fixed-effects model and random-effects model were applied to process these data. Results: There were 13 clinical trials qualified under our selection criteria. The study included 396 stable angina(SA) patients,366 unstable angina(UA) patients,268 acute myocardial infarction(AMI) patients and 446 healthy control group. Meta-analysis showed that the standardized mean difference(SMD)of MCP-1 concentrations in the patients with SA was 0.71(95%CI:0.30~1.12),SMD of UA group was 1.98(95%CI:1.15~2.81),SMD of AMI group was 2.69(95%CI:1.67~3.70). Each SMD of those three groups was higher than that of the healthy control group(P < 0.01). Moreover,serum MCP-1 concentrations in the patients with UA were 0.77 to 2.20 times of standard deviation higher than those in the patients with SA,and the concentrations of serum MCP-1 in the patients with AMI were 0.32 to 0.67 times of standard deviation higher compared to those in the patients with UA. Conclusion: High serum MCP-1 level is associated with the severity of CHD,while the precise relationship between serum MCP-1 concentration and CHD in Chinese population requires prospective study.
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