CHI3L1-329 G/A基因多态性与冠心病相关性的研究
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南京医科大学科技发展基金资助(2010NJMUZ52)


The research of the relationship between CHI3L1-329 G/A polymorphism and coronary artery disease
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    摘要:

    目的:炎症在冠状动脉粥样硬化性心脏病(冠心病,CAD)中起着重要的作用-多项研究中关于几丁质酶3样蛋白1(chitinase 3-like protein 1,CHI3L1)-329 G/A基因多态性与冠心病的关系存在争议-本研究的目的在于观察江苏地区人群中CHI3L1-329 G/A多态性与冠心病的关系-方法:本研究入选391例患者,其中189例CAD,202例正常对照-通过连接酶检测反应(ligase detection reaction,LDR)检测CHI3L1单核苷酸多态性(single nucleotide polymorphism,SNP)位点的基因型及等位基因频率-结果:冠心病患者和正常对照组之间CHI3L1基因型频率分布差别无统计学意义-GA-AA基因型和等位基因G-A频率在心肌梗死组-不稳定性心绞痛组和稳定性心绞痛组中的分布差异有统计学意义(P < 0.05);但是在不同病变血管中分布无差异(P > 0.05)-结论:CHI3LI-329 G/A基因多态性与江苏地区人群的冠心病没有相关性-

    Abstract:

    Objective:To observe the correlation of single-nucleotide polymorphisms(SNPs) of chitinase 3-like protein 1(CHI3L1)-329 G/A and coronary artery disease(CAD) in Jiangsu province. Methods:Total 391 patients were enrolled,including 189 patients with CAD and 202 controls. The SNP at CHI3L1 -329 G/A was genotyped by ligase detection reaction. Results:Analysis of genotype frequencies did not reveal any significant difference between CAD patients and controls. There were significant differences in the frequencies of A allele and A allele carriers among SAP,UAP,and MI groups(P < 0.05 respectively). No associations existed between the SNP and the severity of coronary artery stenosis(All P > 0.05). Conclusion:These results did not support an involvement of SNP rs10399931 of CHI3L1 -329 G/A in predisposition to CAD in Jiangsu area.

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钱 琦,龙明智,陈 忠,马根山. CHI3L1-329 G/A基因多态性与冠心病相关性的研究[J].南京医科大学学报(自然科学版),2012,(6):841-844

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  • 收稿日期:2011-12-13
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