文章摘要
刘培生,陈 鑫,庄 瑜.右旋糖酐40缓解犬体外循环实验模型中的炎症反应[J].南京医科大学学报,2012,(9):1215~1218
右旋糖酐40缓解犬体外循环实验模型中的炎症反应
Dextran-40 reducing the inflammation during cardiopulmonary bypass of the mongrel dog
投稿时间:2012-03-29  
DOI:10.7655
中文关键词: 右旋糖酐  炎症反应  心房纤颤  体外循环
英文关键词: dextran  inflammation  atrial fibrillation  cardiopulmonary bypass
基金项目:南京市医学科技发展青年科技人才启动项目(QYK10136)
作者单位
刘培生 南京医科大学附属南京医院胸心血管外科,江苏 南京 210006 
陈 鑫 南京医科大学附属南京医院胸心血管外科,江苏 南京 210006 
庄 瑜 南京医科大学附属南京医院胸心血管外科,江苏 南京 210006 
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中文摘要:
      目的:建立犬体外循环的模型,研究右旋糖酐40在体外循环后炎症反应中的作用及其对心脏术后心房纤颤的影响?方法:成年杂种犬随机分为两组,常规建立体外循环,分别予以右旋糖酐40及生理盐水静脉滴注?在体外循环转流前?转流开始后20 min?结束后4?24?48 h分别采血检测C反应蛋白(CRP)?白细胞介素(IL)-6?IL-8?IL-10?肿瘤坏死因子α(TNF-α)?肌钙蛋白I(TnI),同时记录心率?血压?心指数?射血分数(EF)值?术后对两组动物采用超速起搏诱导心房纤颤?结果:右旋糖酐40组的炎症因子CRP?IL-6?IL-8?IL-10?TNF-α?TnI表达水平低于对照组?两组房颤诱导率?血压?心率无差异,但右旋糖酐40组体外循环后24 h的EF值及心指数优于对照组?结论:右旋糖酐40可以缓解体外循环中的炎症反应并保护心功能?
英文摘要:
      Objective:To establish the extracorporeal circulation model of the mongrel dog and to investigate the effect of dextran-40 on inflammation and atrial fibrillation after extracorporeal circulation. Methods:Twelve male mongrel dogs underwent cardiac bypass. Two groups were formed. In experimental group(n = 6),dextran-40 infusion was administered at a dose of 7.5 ml/kg before the initiation of cardiopulmonary bypass and at a dose of 12.5 ml/kg after the cessation of cardiopulmonary bypass. Identical amounts of saline was administered in control group(n = 6). Blood samples were taken from the coronary artery and coronary sinus before bypass,20 min after beginning of bypass,and 4 h,24 h,and 48 h after termination of bypass and initiation of reperfusion. Plasma interleukin (IL)-6,IL-8,IL-10,tumor necrosis factor (TNF)-α,C reactive protein (CRP),troponin I (TnI) were measured in these samples. And heart rate,mean blood pressure,ejection fraction (EF) and cardiac index (CI) were measured at the same time point. Pacing-induced atrial fibrillation was compared between two groups. The t test,χ2 test and ANOVA were used for statistical analysis. Results:In experimental group,lower peak plasma levels of IL-6,IL-8,IL-10,TNF-α,CRP and TnI were found. There was no significant difference in heart rate and mean blood pressure between two groups. Higher figures of the cardiac index and ejection fraction were noted in experimental group. Conclusion:Dextran-40 reduces the systemic inflammatory response,cardiac troponin I release,protects cardiac function and may relieve atrial fibrillation following cardiopulmonary bypass.
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