文章摘要
魏子程,程 杰,叶金海,江宏兵,吴煜农.EZH2在舌鳞状细胞癌中的表达及其临床意义[J].南京医科大学学报,2012,(9):1225~1228
EZH2在舌鳞状细胞癌中的表达及其临床意义
The expression and clinical significance of EZH2 in tongue squamous cell carcinoma
投稿时间:2012-05-18  
DOI:10.7655
中文关键词: 舌鳞状细胞癌  EZH2基因  免疫组织化学染色  临床病理
英文关键词: tongue squamous cell carcinoma  EZH2  immunohistochemistry  clinicopathology
基金项目:国家自然科学基金(81100737);江苏省自然科学基金(BK2011762;BK2010531);教育部高等学校博士学科点专项科研基金(20113234120003);江苏省高校优势学科建设工程资助项目(2011-137)
作者单位
魏子程 南京医科大学口腔医学研究所,南京医科大学附属口腔医院口腔颌面外科,江苏 南京 210029 
程 杰 南京医科大学口腔医学研究所,南京医科大学附属口腔医院口腔颌面外科,江苏 南京 210029 
叶金海 南京医科大学口腔医学研究所,南京医科大学附属口腔医院口腔颌面外科,江苏 南京 210029 
江宏兵 南京医科大学口腔医学研究所,南京医科大学附属口腔医院口腔颌面外科,江苏 南京 210029 
吴煜农 南京医科大学口腔医学研究所,南京医科大学附属口腔医院口腔颌面外科,江苏 南京 210029 
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中文摘要:
      目的:探讨EZH2蛋白在舌鳞状细胞癌组织中的表达及其与临床病理的关系?方法:应用免疫组织化学染色法检测EZH2蛋白在52例舌鳞癌组织和12例正常舌组织标本中的表达?结合患者临床病理和随访资料,应用SPSS17.0软件分析EZH2的表达与相关临床病理参数以及患者总生存率之间的关系?结果:EZH2在舌鳞癌组织中呈高表达,与在正常组织中的表达有显著统计学差异(P < 0.001)?EZH2蛋白表达与肿瘤病理学分级(P = 0.033)?颈淋巴结转移(P = 0.036)和局部浸润性(P = 0.012)有关,而与患者的性别?年龄?肿瘤大小?临床分期无关(P > 0.05)?Kaplan-Meier 法分析患者的总体生存情况发现EZH2高表达组患者的总体生存率明显低于EZH2低表达组患者(P = 0.028,Log-rank检验)?结论:EZH2在舌鳞状细胞癌组织中呈高表达,其表达水平与肿瘤病理学分级?颈淋巴结转移?局部浸润性及患者预后有关?
英文摘要:
      Objective:To investigate the enhancer of zeste homolog 2(EZH2) expression in tongue squamous cell carcinoma (TSCC) and its relationship with various clinicopathological parameters. Methods:The EZH2 protein expression in 52 cases of TSCC and 12 cases normal tongue samples was examined by immunohistochemistry. Based on these patients’ information and their follow-up data,the correlations of the EZH2 level with patients’ clinicopathological characteristics and overall survival were further evaluated by statistical analyses using Fisher exact test and Kaplan-Meier method respectively. Results:The EZH2 was over-expressed in TSCC,which was statistically different from that in normal tongue(P < 0.001). EZH2 over-expression was found to be associated with tumor grades(P = 0.033),cervical lymph node metastasis(P = 0.036) and the presence of local invasion (P = 0.012),but not with gender,age,tumor size and clinical stage (P > 0.05). The overall survival rates in patients with EZH2 high expression were significantly lower than those in patients with EZH2 low expression as estimated by Kaplan-Meier method and Log-rank test (P = 0.028). Conclusion:EZH2 is over-expressed in TSCC and its upregulation is associated with tumor grades,cervical lymph node metastasis,local invasiveness and poor prognosis.
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