文章摘要
单鸣凤,郭 君,陈鸿健.212例少年脊柱关节病骶髂关节损害相关危险因素分析[J].南京医科大学学报,2012,(9):1277~1280
212例少年脊柱关节病骶髂关节损害相关危险因素分析
The analysis of the risk factors for sacroiliac joint damage in juvenile-onset spondyloarthropathy
投稿时间:2012-03-23  
DOI:10.7655
中文关键词: 脊柱关节病  少年  骶髂关节损害  危险因素
英文关键词: spondyloarthropathics  juvenile  sacroiliac joint damage  risk factors
基金项目:
作者单位
单鸣凤 南京医科大学附属南京儿童医院感染科,江苏 南京 210008 
郭 君 吉林大学中日联谊医院儿科,吉林 长春 130031 
陈鸿健 南京医科大学附属南京儿童医院感染科,江苏 南京 210008 
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中文摘要:
      目的:探讨少年脊柱关节病(juvenile-onset spondyloarthropathy,JSpA)患者出现骶髂关节损害的相关危险因素,为选择恰当的治疗方案提供依据?方法:对212例JSpA患者的人口学因素?遗传学因素?受累部位?各个实验室指标等进行分析?将患者按照年龄段(≤11岁及12~16岁)分为两组?分别采用Logistic回归的方法进行分析,筛选出JSpA出现骶髂关节损害的相关发病因素?结果:本组212例患者中有骶髂关节损害者124例,占58.5%?单因素分析显示多个因素在骶髂关节损害中有统计学意义;多因素Logistic逐步回归分析显示病程?起病时外周关节炎尤其是下肢大关节?持续肌腱端炎?HLA-B27阳性?家族史是JSpA并发骶髂关节损害的相关危险因素?结论:JSpA患者出现骶髂关节损害的发生率较高,与多种因素有关,当患者出现这些危险因素时,应早期积极干预治疗,定期检查骶髂关节MRI,减轻或延缓病情的进展?
英文摘要:
      Objective:To investigate the risk factors of sacroiliac joint damage in patients with juvenile-onset spondyloarthropathy(JSpA),and to provide reference for the selection of appropriate treatment strategy. Methods:To analysis the clinical data of 212 cases of JSpA,including demographic factors(sex,age),genetic factors,the affected area,laboratories indicators. Patients were divided into two groups according to age (≤ 11 years old and 12~16 years old). Using the Logistic regression to filter out the risk factors of sacroiliac joint damage in patients with JSpA. Results:Out of the 212 cases,124(58.5%) patients suffered from sacroiliac joint damage. Single factor analysis showed that a number of factors were related to sacroiliac joint damage. Logistic regression analysis showed that the course of disease,at the onset of peripheral arthritis,particularly the large joints of lower limbs,tendon-sustained inflammation and HLA-B27-positive,family history were the risk factors of sacroiliac joint damage. Conclusion:The incidence of sacroiliac joint damage in JSpA patients is high and it is associated with multiple factors. For patients with these risk factors,early intervention and MRI examination of sacroiliac joint regularly should be taken to reduce or delay the disease progression.
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