Objective:To discuss the pregnancy and obstetric outcome of the patients after transcervical resection of septum(TCRS). Methods:We collected 166 patients with uterus septa from May 2006 to May 2011 from Nanjing Maternity and Child Health Hospital of Nanjing Medical University,and compared the pregnancy and obstetric outcome between pre-operation and post-operation with medical records,surgical records and telephone follow-up. Results:No serious complications occurred during operation,and the shortest duration from the remove of IUD to pregnancy was one month. After TCRS,the rate of spontaneous abortion decreased from 64.53% to 15.25%(P < 0.01),while the live birth rate increased from 1.89% to 72.03%(P < 0.01). The rate of cesarean section was 80%,in which the cesarean section without indications was 41.12%. Besides,the incidence of postpartum hemorrhage was 23.53%,in which the rate of blood transfusion patients was 45% including one threatened uterine rupture case in our study. Conclusion:TCRS could significantly promote the pregnancy and improve outcomes after surgery. Intensive pregnancy monitoring and sufficiently guidance were essential to improve the obstetric outcome and prevent postpartum hemorrhage.