Objective:To explore the association of genetic polymorphisms in complement component C3 with ischemic stroke risk in the ethnic Han of Eastern China. Methods:A total of 700 cases with ischemic stroke and the control group of 700 cases were recruited. Polymorphisms were rs2277984 G/A,rs37455652 G/C genotyped by TaqMan fluorescence probe. The multivariate Logistic regression model was used to exclude the effects of conventional risk factors on ischemic stroke. Results:The rs2277984 variant was not associated with ischemic stroke risk;the rs3745565 GG/CC genotype,only if under the dominant genetic model and uncorrected,had an increased risk of ischemic stroke (OR = 1.37,95%CI 1.04-1.80,P = 0.026). The rs3745565 variant was not associated with ischemic stroke risk after adjusting confounding factor (P > 0.05). Conclusion:The present study suggested that genetic polymorphisms in complement component C3 (rs2277984 and rs3745565) may not exert influences on ischemic stroke susceptibility among the ethnic Han of Eastern China.