文章摘要
曹维娟,王淦楠,孙 昊,吕清泉,苏成磊,张劲松.补体C3基因多态性与中国华东地区汉族人群缺血性脑卒中易感性的分子流行病学研究[J].南京医科大学学报,2013,(1):53~58
补体C3基因多态性与中国华东地区汉族人群缺血性脑卒中易感性的分子流行病学研究
An association study of genetic polymorphisms in complement component C3 and ischemic stroke susceptibility in the ethnic Han of Eastern china
投稿时间:2012-11-22  
DOI:10.7655/NYDXBNS20130111
中文关键词: 补体C3  基因多态性  缺血性脑卒中
英文关键词: complement component C3  genetic polymorphisms  ischemic stroke
基金项目:江苏省卫生厅医学科研项目(H201005);江苏省医学创新团队与领军人才项目(LJ201122);江苏高校优势学科建设工程资助项目(JX10231801)
作者单位
曹维娟 南京医科大学第一附属医院急诊医学中心,江苏 南京 210029 
王淦楠 南京医科大学第一附属医院急诊医学中心,江苏 南京 210029 
孙 昊 南京医科大学第一附属医院急诊医学中心,江苏 南京 210029 
吕清泉 南京医科大学第一附属医院急诊医学中心,江苏 南京 210029 
苏成磊 南京医科大学第一附属医院急诊医学中心,江苏 南京 210029 
张劲松 南京医科大学第一附属医院急诊医学中心,江苏 南京 210029 
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中文摘要:
      目的:探讨补体C3基因多态性与中国华东地区汉族人群缺血性脑卒中(ischemic stroke,IS)易感性之间的关系。方法:收集IS病例组及对照组各700例,采用TaqMan荧光探针法对所有研究对象进行rs2277984 G/A?rs3745565G/C位点基因型检测,多因素Logistic回归方法校正传统危险因素后分析各位点多态性与IS发病风险的独立相关性。结果:rs2277984多态性与IS易感性无相关性;rs3745565仅在显性遗传模式下?未进行校正时,其GC/CC基因型增加了IS的发病风险(OR = 1.37,95%CI 1.04~1.80,P = 0.026),在调整混杂因素后与IS易感性不相关(P > 0.05)。结论:C3基因多态性的2个基因位点可能不影响本地区IS的发病风险。
英文摘要:
      Objective:To explore the association of genetic polymorphisms in complement component C3 with ischemic stroke risk in the ethnic Han of Eastern China. Methods:A total of 700 cases with ischemic stroke and the control group of 700 cases were recruited. Polymorphisms were rs2277984 G/A,rs37455652 G/C genotyped by TaqMan fluorescence probe. The multivariate Logistic regression model was used to exclude the effects of conventional risk factors on ischemic stroke. Results:The rs2277984 variant was not associated with ischemic stroke risk;the rs3745565 GG/CC genotype,only if under the dominant genetic model and uncorrected,had an increased risk of ischemic stroke (OR = 1.37,95%CI 1.04-1.80,P = 0.026). The rs3745565 variant was not associated with ischemic stroke risk after adjusting confounding factor (P > 0.05). Conclusion:The present study suggested that genetic polymorphisms in complement component C3 (rs2277984 and rs3745565) may not exert influences on ischemic stroke susceptibility among the ethnic Han of Eastern China.
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