文章摘要
苏 波,云 鹏.甲状腺功能亢进性心脏病猝死者左心室心肌连接蛋白43的分布改变[J].南京医科大学学报,2013,(1):86~89
甲状腺功能亢进性心脏病猝死者左心室心肌连接蛋白43的分布改变
Changes of connexin 43 distribution in myocardial cell of the left ventricle in the cases of sudden-death due to hyperthyroid heart disease
投稿时间:2012-10-30  
DOI:10.7655/NYDXBNS20130118
中文关键词: 连接蛋白43  甲亢性心脏病  免疫组织化学  法医病理学
英文关键词: connexin 43  hyperthyroid heart disease  immunohistochemistry  forensic pathology
基金项目:湖北省教育厅资助项目(XD2010185)
作者单位
苏 波 长江大学医学院病理学教研室,湖北 荆州 434000 
云 鹏 长江大学临床医学院内科学教研室,湖北 荆州 434000 
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中文摘要:
      目的:探讨甲亢性心脏病猝死者心肌连接蛋白 43 (myocardial connexin 43,Cx43)表达及其与猝死的关系。方法:挑选长江大学医学院病理学教研室2010~2012年尸体解剖案例26例,分为2组,每组各13例。①实验组:男9例,女4例,年龄20~52岁,平均年龄34.7岁,均为甲亢性心脏病猝死。②非心源性死亡对照组:男7例,女6例,年龄22~60岁,平均年龄38.8岁。每例心脏进行常规病理学检查并取材后,运用免疫组织化学和图像分析技术,检测左心室肌的Cx43染色情况。结果:实验组心肌Cx43阳性颗粒数分布于心室肌细胞内或细胞侧-侧连接处;对照组心肌Cx43阳性颗粒数分布于闰盘。定量检测并经统计分析发现,实验组Cx43蛋白染色阳性的面积和与对照组均有非常显著的差异(P < 0.01),而平均光密度比较,两组之间差异无统计学意义(P > 0.05)。结论:甲亢性心脏病猝死者心室肌 Cx43蛋白的分布发生明显改变,甲亢性心脏病的猝死可能与Cx43的分布变化有一定的关系。
英文摘要:
      Objective:To investigate the relationship between the expression of myocardial connexin 43 (Cx43)in myocardial cell of the left ventricle in the cases of sudden-death due to hyperthyroid heart disease. Methods:Selected 26 autopsy cases from the Department of Forensic Medicine School of medicine,Yangtze University during 2010 to 2012. The cases were divided into two groups,13 cases in each group. ①Experimental group:9 cases male,4 female;age range is 20 to 52 with average age is 34.7 years old,Suddenly died of hyperthyroid heart disease and sudden death. ②Control group:7 males,6 females,age range is 22-60 with average age is 38.8 years old. After conventional pathological examination,Cx43 in the left ventricular muscle of each case was detected with immunohistochemic staining and image analysis. Results:In control group,the Cx43 positive staining were found in the intercalated disc. In experimental group,the Cx43 positive staining were found in the cytoplasm or side-side connection of ventricular myocyte,and the positive area of Cx43 positive particles were significantly decreased than control group (P < 0.01). Conclusion:The expression of myocardial connexin (Cx43)was significantly decreased in sudden-death patients with hyperthyroid heart disease,which suggests the decreased expression of Cx43 may have relation with sudden death of hyperthyroid heart disease.
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