文章摘要
刘 邺,成 建.南京地区妇女宫颈人乳头瘤病毒感染和亚型分布情况[J].南京医科大学学报,2013,(2):206~209
南京地区妇女宫颈人乳头瘤病毒感染和亚型分布情况
Prevalence and genotype distribution of cervical human papillomavirus infection among women in Nanjing
投稿时间:2012-09-11  
DOI:10.7655/NYDXBNS20130213
中文关键词: 人乳头瘤病毒  基因分型
英文关键词: human papillomavirus  genotype
基金项目:南京医科大学科技发展基金重点项目(2011NJMU215)
作者单位
刘 邺 南京医科大学附属南京妇幼保健院产前诊断中心,江苏 南京 210004 
成 建 南京医科大学附属南京妇幼保健院产前诊断中心,江苏 南京 210004 
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中文摘要:
      目的:了解南京地区妇女宫颈人乳头瘤病毒(human papillomavirus,HPV)感染及亚型分布情况。方法:用核酸分子芯片快速杂交法对7 531名妇女进行宫颈脱落细胞HPV DNA基因分型检测,并对HPV感染率?亚型分布进行统计分析。结果:南京地区妇女宫颈部位HPV感染率为33.0%(年龄标准化率为37.3%);在2 485例HPV感染者中,≤24岁年龄组妇女感染率最高,为43.3% ,各年龄组间HPV感染率有显著性差异;≤24岁年龄组妇女多重亚型感染率最高,为40.0%,各年龄组间的多重亚型感染率有显著性差异;在所检测出来的21种亚型中,HPV16?58?52是最常见的高危亚型,感染率分别为8.6%?7.6%?5.2%。结论:南京地区≤24岁妇女宫颈部位HPV感染率较高,应作为宫颈疾病预防的重点人群。HPV16?HPV58?HPV52是该地区妇女宫颈部位最常见的感染亚型。
英文摘要:
      Objective:To analyze the prevalence and genotype distribution of cervical human papillomavirus (HPV) infection among women in Nanjing,China. Methods:Fast nucleic acid hybridization chip was performed to detect cervical HPV DNA and genotype of 7 531 women and the prevalence and genotype distribution were analyzed. Results:The overall prevalence of cervical HPV infection was 33.0% among women in Nanjing(age-standardized prevalence was 37.3%). Among 2 485 HPV-positive women,the overall prevalence of HPV infection was highest in the group aged ≤24 years(43.3%)and there was significant difference between the prevalence of different age-stratified group;the overall prevalence of multiple genotypes HPV infection was highest in the group aged ≤24 years(40.0%)and there was significant difference between the prevalence of different age-stratified group;among the detected 21 HPV genotypes,the most common high-risk HPV genotypes were HPV16(8.6%),HPV58(7.6%),HPV52(5.2%). Conclusion:The prevalence of cervical human papillomavirus among women aged ≤24 years in Nanjing was relatively high,cervical disease prevention program should give priority to this population;HPV 16,HPV 58 and HPV 52 were the most prevalent cervical HPV genotypes among women in Nanjing.
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