文章摘要
陈兰兰,万 琪,玄丽慧,景 坚,李 军.栓塞为腔隙性脑梗死重要发病机制[J].南京医科大学学报,2013,(2):221~225
栓塞为腔隙性脑梗死重要发病机制
Embolism is an important mechanism of lacunar infarction
投稿时间:2012-08-13  
DOI:10.7655/NYDXBNS20130217
中文关键词: 腔隙性脑梗死  栓塞  血管狭窄  斑块
英文关键词: lacunar infarction  embolism  stenosis  plaque
基金项目:
作者单位
陈兰兰 江苏省苏北人民医院神经内科,扬州大学临床医学院,江苏 扬州 225001 
万 琪 南京医科大学第一附属医院神经内科,江苏 南京 210029 
玄丽慧 江苏省苏北人民医院神经内科,扬州大学临床医学院,江苏 扬州 225001 
景 坚 江苏省苏北人民医院神经内科,扬州大学临床医学院,江苏 扬州 225001 
李 军 江苏省苏北人民医院神经内科,扬州大学临床医学院,江苏 扬州 225001 
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中文摘要:
      目的:探讨栓塞是否及如何参与腔隙性脑梗死(lacunar infarction,LI)的发病过程。方法:回顾性收集2008年8月~2012年6月所有入住本院的急性脑梗死患者,排除心源性栓塞及其他原因脑梗死,根据梗死面积分为LI组及非LI组,比较两组的危险因素及血管情况。结果:两组间各危险因素均无明显差异(P > 0.05);两组的责任血管斑块及狭窄率均明显多于非责任血管侧(P < 0.05);LI组的责任血管斑块率?狭窄率以及进展性和多发性脑梗死的发生率明显低于非LI组(P < 0.05);LI组与非LI组间的进展性脑梗死的责任血管斑块和狭窄率以及多发性脑梗死的责任血管斑块率无明显差异(P > 0.05),而多发性脑梗死的责任血管狭窄率明显低于非LI组(P < 0.05)。结论:栓塞参与了LI的发病过程,但非其主导发病机制。
英文摘要:
      Objective:To evaluate the role of embolism in lacunar infarction(LI). Methods:Consecutive patients admitted to our hospital with acute cerebral infarction from Oct. 2008 to Jun. 2011 were reviewed. Patients with cardioembolism or other determined etiologies were excluded while other patients were divided into two groups,including the LI group and the non-LI group according to the diameter of infraction. Risk factors and arteries plaques and stenosis of two groups were analyzed. Results:There was no statistical difference of every risk factor between two groups(P > 0.05);the plaques and stenosis in the territory arteries were significantly more frequent than that in the contralateral side in both groups(P < 0.05);the plaques and stenosis in the territory arteries and the progressive and multiple infraction were significantly less frequent in the LI group than in the non-LI group (P < 0.05);the differences of plaques and stenosis in the territory arteries of progressive infraction and plaques of multiple infraction between two groups were of no significance(P > 0.05),but stenosis in the territory arteries of multiple infraction was significantly less frequent in the LI group than in the non-LI group (P < 0.05). Conclusion:Embolism is an important but not dominant mechanism in lacunar infarction.
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