Objective:To investigate the prevalence and influential factors of anxiety and depression in patients with primary open-angle glaucoma (POAG) before and after surgical interventions. Methods:Totally 83 patients with POAG were investigated with Hamilton anxiety scale (HAMA),Hamilton depression scale(HAMD),family support scale and low vision quality-of-life questionnaire (LVQOL) preoperatively,and with LVQOL,HAMA and HAMD in one-month-post operative time. Totally 83 controls were assessed by using HAMA and HAMD. We investigated the prevalence and influential factors of anxiety and depression in patients with POAG before and after surgical interventions. Results:Of all the POAG patients,49(59.0%) of them were identified as anxiety and 25 (30.1%) of them were identified as depression preoperatively. A total of 17(20.5%) patients were identified as anxiety,and 13 (15.7%) patients were identified as depression in one-month-post operative time,whereas the incidence of anxiety and depression in the control group was 8.4% and 4.8%,respectively. Multiple linear regression analysis showed that preoperative HAMA scores were correlated with sex and family support whereas preoperative HAMD scores were correlated with sex,QOL,family support and age (P < 0.05). In multivariate logistic regression,the impact factors of anxiety in one-month-postoperative time were age and QOL (P = 0.027,P = 0.009);QOL was the factor affecting depression in one-month-postoperative time (P = 0.047). Conclusion:There existed high prevalence of anxiety and depression disorders with POAG patients before and after surgical interventions and more attentions should be paid on this phenomenon.